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Abl2 blocking peptide

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Catalog # MBS9230131
Unit / Price
  0.1 mg  /  $155 +1 FREE 8GB USB
Abl2 blocking peptide
Product Name

Abl2, Blocking Peptide

Also Known As

Mouse Abl2 Blocking Peptide (C-term)

Product Synonym Names
Abelson tyrosine-protein kinase 2; Abelson murine leukemia viral oncogene homolog 2; Abelson-related gene protein; Tyrosine-protein kinase ARG; Abl2
Antibody/Peptide Pairs
Abl2 peptide (MBS9230131) is used for blocking the activity of Abl2 antibody (MBS9216252)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Length
1182
3D Structure
ModBase 3D Structure for Q4JIM5
Specificity
The synthetic peptide sequence is selected from aa 1011-1024 of HUMAN Abl2
Form/Format
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Cellular Location
Cytoplasm, cytoskeleton
Tissue Location
Most abundant in adult mouse brain, especially in synapse-rich regions.
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Other Notes
Small volumes of Abl2 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
Abl2 blocking peptide
Non-receptor tyrosine-protein kinase that plays an ABL1- overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10 (involved in movement); CTTN (involved in signaling); or TUBA1 and TUBB (microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin-bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL or DOK1. Required for adhesion-dependent phosphorylation of ARHGAP35 which promotes its association with RASA1, resulting in recruitment of ARHGAP35 to the cell periphery where it inhibits RHO. Phosphorylates multiple receptor tyrosine kinases like PDGFRB and other substrates which are involved in endocytosis regulation such as RIN1. In brain, may regulate neurotransmission by phosphorylating proteins at the synapse. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1.
NCBI/Uniprot data below describe general gene information for Abl2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Related Accession #
Molecular Weight
128,196 Da
NCBI Official Full Name
Abelson tyrosine-protein kinase 2
NCBI Official Synonym Full Names
v-abl Abelson murine leukemia viral oncogene 2 (arg, Abelson-related gene)
NCBI Official Symbol
NCBI Official Synonym Symbols
Arg; Abll; AA536808
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NCBI Protein Information
Abelson tyrosine-protein kinase 2
UniProt Protein Name
Abelson tyrosine-protein kinase 2
UniProt Synonym Protein Names
Abelson murine leukemia viral oncogene homolog 2; Abelson-related gene protein; Tyrosine-protein kinase ARG
UniProt Gene Name
UniProt Entry Name
ABL2_MOUSE
UniProt Comments for Abl2
Arg: a cytoplasmic tyrosine kinase of the Abl family. Expressed at the highest levels in mature B cells. Promotes catalase degradation in the oxidative stress response. Localizes to dynamic actin structures and may regulate cytoskeleton remodeling during cell differentiation, cell division and cell adhesion. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Kinase, protein; EC 2.7.10.2; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); Oncoprotein; TK group; Abl family

Cellular Component: actin cytoskeleton; cytoplasmic membrane-bound vesicle; dendritic spine; extrinsic to internal side of plasma membrane; lamellipodium; phagocytic cup

Molecular Function: magnesium ion binding; manganese ion binding; non-membrane spanning protein tyrosine kinase activity; protein binding; protein-tyrosine kinase activity

Biological Process: actin cytoskeleton organization and biogenesis; actin filament bundle formation; actin filament organization; alpha-beta T cell differentiation; Bergmann glial cell differentiation; cerebellum morphogenesis; dendrite morphogenesis; elevation of cytosolic calcium ion concentration; epidermal growth factor receptor signaling pathway; innate immune response; learning; negative regulation of cell-cell adhesion; negative regulation of Rho protein signal transduction; neuromuscular process controlling balance; neuron remodeling; peptidyl-tyrosine phosphorylation; phagocytosis; platelet-derived growth factor receptor signaling pathway; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of oxidoreductase activity; positive regulation of protein binding; protein amino acid phosphorylation; regulation of cell proliferation; substrate-bound cell migration, cell extension; visual learning
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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