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ACADL blocking peptide

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Catalog # MBS9219686
Unit / Price
  0.1 mg  /  $155 +1 FREE 8GB USB
ACADL blocking peptide
Product Name

ACADL, Blocking Peptide

Also Known As

ACADL Antibody (N-term) Blocking Peptide

Product Synonym Names
Long-chain specific acyl-CoA dehydrogenase; mitochondrial; LCAD; ACADL
Antibody/Peptide Pairs
ACADL peptide (MBS9219686) is used for blocking the activity of ACADL antibody (MBS9204274)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Length
430
OMIM
201475
3D Structure
ModBase 3D Structure for P28330
Specificity
The synthetic peptide sequence used to generate the antibody was selected from the N-term region of ACADL. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Form/Format
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Cellular Location
Mitochondrion matrix.
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Other Notes
Small volumes of ACADL blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for ACADL. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
47,656 Da
NCBI Official Full Name
Long-chain specific acyl-CoA dehydrogenase, mitochondrial
NCBI Official Synonym Full Names
acyl-CoA dehydrogenase, long chain
NCBI Official Symbol
ACADL  [Similar Products]
NCBI Official Synonym Symbols
LCAD; ACAD4
  [Similar Products]
NCBI Protein Information
long-chain specific acyl-CoA dehydrogenase, mitochondrial
UniProt Protein Name
Long-chain specific acyl-CoA dehydrogenase, mitochondrial
UniProt Gene Name
ACADL  [Similar Products]
UniProt Synonym Gene Names
UniProt Entry Name
ACADL_HUMAN
NCBI Summary for ACADL
The protein encoded by this gene belongs to the acyl-CoA dehydrogenase family, which is a family of mitochondrial flavoenzymes involved in fatty acid and branched chain amino-acid metabolism. This protein is one of the four enzymes that catalyze the initial step of mitochondrial beta-oxidation of straight-chain fatty acid. Defects in this gene are the cause of long-chain acyl-CoA dehydrogenase (LCAD) deficiency, leading to nonketotic hypoglycemia. [provided by RefSeq, Jul 2008]
UniProt Comments for ACADL
ACADL: Defects in ACADL are a cause of acyl-CoA dehydrogenase very long-chain deficiency (ACADVLD). An inborn error of mitochondrial fatty acid beta-oxidation which leads to impaired long-chain fatty acid beta-oxidation. It is clinically heterogeneous, with three major phenotypes: a severe childhood form characterized by early onset, high mortality and high incidence of cardiomyopathy; a milder childhood form with later onset, characterized by hypoketotic hypoglycemia, low mortality and rare cardiomyopathy; an adult form, with isolated skeletal muscle involvement, rhabdomyolysis and myoglobinuria, usually triggered by exercise or fasting. Belongs to the acyl-CoA dehydrogenase family.

Protein type: EC 1.3.8.8; Mitochondrial; Oxidoreductase; Lipid Metabolism - fatty acid

Chromosomal Location of Human Ortholog: 2q34

Cellular Component: mitochondrial matrix; mitochondrion

Molecular Function: acyl-CoA binding; acyl-CoA dehydrogenase activity; electron carrier activity; FAD binding; long-chain-acyl-CoA dehydrogenase activity; palmitoyl-CoA oxidase activity

Biological Process: carnitine catabolic process; carnitine metabolic process, CoA-linked; cellular lipid catabolic process; fatty acid beta-oxidation; fatty acid beta-oxidation using acyl-CoA dehydrogenase; lipid homeostasis; long-chain fatty acid catabolic process; negative regulation of fatty acid biosynthetic process; negative regulation of fatty acid oxidation; thermoregulation
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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