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ACADM recombinant protein :: Medium-chain specific acyl-CoA dehydrogenase, mitochondrial Recombinant Protein

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Catalog # MBS957818
Unit / Price
  0.01 mg (E-Coli)  /  $135 +1 FREE 8GB USB
  0.05 mg (E-Coli)  /  $255 +1 FREE 8GB USB
  0.1 mg (E-Coli)  /  $420 +1 FREE 8GB USB
  0.2 mg (E-Coli)  /  $665 +1 FREE 8GB USB
  0.05 mg (Yeast)  /  $915 +1 FREE 8GB USB
  0.05 mg (Baculovirus)  /  $1,045 +1 FREE 8GB USB
  0.5 mg (E-Coli)  /  $1,090 +1 FREE 8GB USB
  0.2 mg (Yeast)  /  $1,230 +1 FREE 8GB USB
  0.05 mg (Mammalian-Cell)  /  $1,295 +1 FREE 8GB USB
  0.1 mg (Baculovirus)  /  $1,325 +1 FREE 8GB USB
  0.5 mg (Yeast)  /  $1,395 +1 FREE 8GB USB
  1 mg (E-Coli)  /  $1,725 +2 FREE 8GB USB
  0.5 mg (Baculovirus)  /  $1,905 +2 FREE 8GB USB
  0.1 mg (Mammalian-Cell)  /  $1,955 +2 FREE 8GB USB
  1 mg (Yeast)  /  $2,115 +2 FREE 8GB USB
  1 mg (Baculovirus)  /  $2,515 +3 FREE 8GB USB
SDS-PAGE
Product Name

Medium-chain specific acyl-CoA dehydrogenase, mitochondrial (ACADM), Recombinant Protein

Popular Item
Also Known As

Recombinant Human Medium-chain specific acyl-CoA dehydrogenase, mitochondrial

Product Synonym Names
MCAD
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
MBS957818 COA
Sequence Positions
26-421aa; Full Length
Sequence Length
421
Sequence
KANRQREPGL GFSFEFTEQQ KEFQATARKF AREEIIPVAA EYDKTGEYPV PLIRRAWELG LMNTHIPENC GGLGLGTFDA CLISEELAYG CTGVQTAIEG NSLGQMPIII AGNDQQKKKY LGRMTEEPLM CAYCVTEPGA GSDVAGIKTK AEKKGDEYII NGQKMWITNG GKANWYFLLA RSDPDPKAPA NKAFTGFIVE ADTPGIQIGR KELNMGQRCS DTRGIVFEDV KVPKENVLIG DGAGFKVAMG AFDKTRPVVA AGAVGLAQRA LDEATKYALE RKTFGKLLVE HQAISFMLAE MAMKVELARM SYQRAAWEVD SGRRNTYYAS IAKAFAGDIA NQLATDAVQI LGGNGFNTEY PVEKLMRDAK IYQIYEGTSQ IQRLIVAREH IDKYKN
OMIM
201450
3D Structure
ModBase 3D Structure for P11310
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
Greater than 90% as determined by SDS-PAGE. (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Homo sapiens (Human)
Preparation and Storage
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of ACADM recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
ACADM recombinant protein
This enzyme is specific for acyl chain lengths of 4 to 16.
Product Categories/Family for ACADM recombinant protein

ACADM recombinant protein SDS-PAGE image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
NCBI/Uniprot data below describe general gene information for ACADM. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
47.72kD
NCBI Official Full Name
medium-chain specific acyl-CoA dehydrogenase, mitochondrial isoform a
NCBI Official Synonym Full Names
acyl-CoA dehydrogenase, C-4 to C-12 straight chain
NCBI Official Symbol
ACADM  [Similar Products]
NCBI Official Synonym Symbols
MCAD; ACAD1; MCADH
  [Similar Products]
NCBI Protein Information
medium-chain specific acyl-CoA dehydrogenase, mitochondrial
UniProt Protein Name
Medium-chain specific acyl-CoA dehydrogenase, mitochondrial
UniProt Gene Name
ACADM  [Similar Products]
UniProt Synonym Gene Names
UniProt Entry Name
ACADM_HUMAN
NCBI Summary for ACADM
This gene encodes the medium-chain specific (C4 to C12 straight chain) acyl-Coenzyme A dehydrogenase. The homotetramer enzyme catalyzes the initial step of the mitochondrial fatty acid beta-oxidation pathway. Defects in this gene cause medium-chain acyl-CoA dehydrogenase deficiency, a disease characterized by hepatic dysfunction, fasting hypoglycemia, and encephalopathy, which can result in infantile death. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for ACADM
ACADM: This enzyme is specific for acyl chain lengths of 4 to 16. Defects in ACADM are the cause of acyl-CoA dehydrogenase medium-chain deficiency (ACADMD). It is an autosomal recessive disease which causes fasting hypoglycemia, hepatic dysfunction, and encephalopathy, often resulting in death in infancy. Belongs to the acyl-CoA dehydrogenase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 1.3.8.7; Mitochondrial; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Carbohydrate Metabolism - propanoate; Oxidoreductase; Lipid Metabolism - fatty acid; Other Amino Acids Metabolism - beta-alanine

Chromosomal Location of Human Ortholog: 1p31

Cellular Component: axon; mitochondrial matrix; mitochondrion; nucleus; peroxisome

Molecular Function: acyl-CoA binding; acyl-CoA dehydrogenase activity; electron carrier activity; FAD binding; identical protein binding

Biological Process: carnitine biosynthetic process; carnitine metabolic process, CoA-linked; cellular lipid metabolic process; fatty acid beta-oxidation; fatty acid beta-oxidation using acyl-CoA dehydrogenase; lipid homeostasis; medium-chain fatty acid catabolic process; medium-chain fatty acid metabolic process

Disease: Acyl-coa Dehydrogenase, Medium-chain, Deficiency Of
Product References and Citations for ACADM recombinant protein
"Nucleotide sequence of medium-chain acyl-CoA dehydrogenase mRNA and its expression in enzyme-deficient human tissue." Kelly D.P., Kim J.-J.P., Billadello J.J., Hainline B.E., Chu T.W., Strauss A.W. Proc. Natl. Acad. Sci. U.S.A. 84:4068-4072(1987)

Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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