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anti-ACAN antibody :: anti-Human, Rat Aggrecan Antibody

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Catalog # MBS856610
Unit / Price
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  0.1 mg  /  $215 +1 FREE 8GB USB
Product Name

Aggrecan (ACAN), Antibody

Full Product Name

Aggrecan (Cleaved-Asp369) Antibody

Product Synonym Names
CSPG1; CSPGCP; MSK16; CHONDROITIN SULFATE PROTEOGLYCAN CORE PROTEIN 1; aggrecan 1 (chondroitin sulfate proteoglycan 1; large aggregating proteoglycan; antigen identified by monoclonal antibody A0122); aggrecan 1 isoform 1 precursor; aggrecan 1 isoform 2 precursor; cartilage-specific proteoglycan core protein
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
155760
3D Structure
ModBase 3D Structure for P16112
Species Reactivity
Human, Rat
Specificity
Aggrecan (Cleaved-Asp369) antibody detects endogenous levels of fragment of activated Aggrecan resulting from cleavage adjacent to Asp369.
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Form/Format
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Immunogen
The antiserum was produced against synthesized peptide derived from human Aggrecan.
All Sites
Human: Asp369
Rat: Asp369
Preparation and Storage
Store at-20 degree C for 1 year
Other Notes
Small volumes of anti-ACAN antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-ACAN antibody
Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)
Application Notes for anti-ACAN antibody
WB: 1:500~1:1000
IHC: 1:50~1:100
ELISA: 1:20000

Immunohistochemistry (IHC) of anti-ACAN antibody
Cl-Peptide-+ Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue using Aggrecan (Cleaved-Asp369) antibody (#L0101).
anti-ACAN antibody Immunohistochemistry (IHC) (IHC) image
Western Blot (WB) of anti-ACAN antibody
Western blot analysis of extracts from Jurkat cells, treated with Etoposide (25uM, 60mins), using Aggrecan (Cleaved-Asp369) antibody (#L0101).
anti-ACAN antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for ACAN. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
250,372 Da[Similar Products]
NCBI Official Full Name
aggrecan core protein isoform 1
NCBI Official Synonym Full Names
aggrecan
NCBI Official Symbol
NCBI Official Synonym Symbols
AGC1; SEDK; AGCAN; CSPG1; MSK16; CSPGCP; SSOAOD
  [Similar Products]
NCBI Protein Information
aggrecan core protein
UniProt Protein Name
Aggrecan core protein
UniProt Synonym Protein Names
Cartilage-specific proteoglycan core protein; CSPCP
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
AGC1; CSPG1; MSK16; CSPCP; Chondroitin sulfate proteoglycan 1  [Similar Products]
NCBI Summary for ACAN
This gene is a member of the aggrecan/versican proteoglycan family. The encoded protein is an integral part of the extracellular matrix in cartilagenous tissue and it withstands compression in cartilage. Mutations in this gene may be involved in skeletal dysplasia and spinal degeneration. Multiple alternatively spliced transcript variants that encode different protein isoforms have been observed in this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for ACAN
This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region.
Product References and Citations for anti-ACAN antibody
Ichiro Sekiya, J. Biol. Chem., Apr 2000; 275: 10738. Ying Liu, J. Biol. Chem., Nov 1997; 272: 29880. Russell T. Matthews, J. Neurosci., Sep 2002; 22: 7536. Amit Agrawal, Am J Physiol Cell Physiol, Apr 2007; 10.1152.

Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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