NP_004760
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
NCBI Official Full Name
acid-sensing ion channel 3 isoform a
NCBI Official Synonym Full Names
acid sensing ion channel subunit 3
NCBI Protein Information
acid-sensing ion channel 3
UniProt Protein Name
Acid-sensing ion channel 3
UniProt Synonym Protein Names
Amiloride-sensitive cation channel 3; Neuronal amiloride-sensitive cation channel 3; Testis sodium channel 1; hTNaC1
UniProt Synonym Gene Names
UniProt Entry Name
ASIC3_HUMAN
NCBI Summary for ACCN3
This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, two hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene is an acid sensor and may play an important role in the detection of lasting pH changes. In addition, a heteromeric association between this member and acid-sensing (proton-gated) ion channel 2 has been observed as proton-gated channels sensitive to gadolinium. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2012]
UniProt Comments for ACCN3
ASIC3: Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Generates a biphasic current with a fast inactivating and a slow sustained phase. In sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic, damaged or inflamed tissue. May be involved in hyperalgesia. May play a role in mechanoreception. Heteromeric channel assembly seems to modulate channel properties. Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC3 subfamily. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Transporter, ion channel; Membrane protein, integral; Channel, cation; Transporter; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 7q35
Cellular Component: integral to plasma membrane; cytoplasm; plasma membrane
Molecular Function: amiloride-sensitive sodium channel activity; enterobactin transporter activity; cation channel activity; sodium channel activity; PDZ domain binding
Biological Process: detection of mechanical stimulus involved in sensory perception of pain; detection of chemical stimulus involved in sensory perception of pain; transport; response to heat; sensory perception; sensory perception of sour taste; enterobactin transport; response to acidity; detection of temperature stimulus involved in sensory perception of pain; signal transduction; transmembrane transport
Research Articles on ACCN3
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Products associated with ACCN3 blocking peptide
Diseases associated with ACCN3 blocking peptide
Organs/Tissues associated with ACCN3 blocking peptide
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