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ACLY recombinant protein :: ATP-citrate synthase Recombinant Protein

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Catalog # MBS953878
Unit / Price
Scan QR to view Datasheet
  0.01 mg (E-Coli)  /  $200 +1 FREE 8GB USB
  0.05 mg (E-Coli)  /  $260 +1 FREE 8GB USB
  0.1 mg (E-Coli)  /  $430 +1 FREE 8GB USB
  0.2 mg (E-Coli)  /  $685 +1 FREE 8GB USB
  0.5 mg (E-Coli)  /  $1,125 +1 FREE 8GB USB
  1 mg (E-Coli)  /  $1,725 +2 FREE 8GB USB
SDS-Page
Product Name

ATP-citrate synthase (ACLY), Recombinant Protein

Popular Item
Full Product Name

Recombinant Human ATP-citrate synthase

Product Synonym Names
ATP-citrate (pro-S-)-lyase; ACL; Citrate cleavage enzyme
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
4-265aa; Partial
Sequence
KAISEQTGKE LLYKFICTTS AIQNRFKYAR VTPDTDWARL LQDHPWLLSQ NLVVKPDQLI KRRGKLGLVG VNLTLDGVKS WLKPRLGQEA TVGKATGFLK NFLIEPFVPH SQAEEFYVCI YATREGDYVL FHHEGGVDVG DVDAKAQKLL VGVDEKLNPE DIKKHLLVHA PEDKKEILAS FISGLFNFYE DLYFTYLEIN PLVVTKDGVY VLDLAAKVDA TADYICKVKW GDIEFPPPFG REAYPEEAYI ADLDAKSGAS LK
OMIM
108728
3D Structure
ModBase 3D Structure for P53396
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
Greater than 90% as determined by SDS-PAGE. (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Homo sapiens (Human)
Preparation and Storage
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of ACLY recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
ACLY recombinant protein
ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine.
Product Categories/Family for ACLY recombinant protein

ACLY recombinant protein SDS-Page image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
NCBI/Uniprot data below describe general gene information for ACLY. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
45.46kD
NCBI Official Full Name
ATP-citrate synthase isoform 1
NCBI Official Synonym Full Names
ATP citrate lyase
NCBI Official Symbol
NCBI Official Synonym Symbols
ACL; ATPCL; CLATP
  [Similar Products]
NCBI Protein Information
ATP-citrate synthase
UniProt Protein Name
ATP-citrate synthase
UniProt Synonym Protein Names
ATP-citrate (pro-S-)-lyase; ACL; Citrate cleavage enzyme
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
UniProt Entry Name
ACLY_HUMAN
NCBI Summary for ACLY
ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Dec 2014]
UniProt Comments for ACLY
ACLY: ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine. Homotetramer. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transferase; Carbohydrate Metabolism - citrate (TCA) cycle; EC 2.3.3.8; Lyase

Chromosomal Location of Human Ortholog: 17q21.2

Cellular Component: cytoplasm; cytosol; membrane; mitochondrion; nucleoplasm; plasma membrane

Molecular Function: ATP binding; ATP citrate synthase activity; cofactor binding; metal ion binding; protein binding

Biological Process: acetyl-CoA biosynthetic process; cellular lipid metabolic process; cholesterol biosynthetic process; citrate metabolic process; energy reserve metabolic process; fatty acid biosynthetic process; lipid biosynthetic process; oxaloacetate metabolic process; positive regulation of cellular metabolic process; triacylglycerol biosynthetic process
Product References and Citations for ACLY recombinant protein
"Cloning and expression of a human ATP-citrate lyase cDNA." Elshourbagy N.A., Near J.C., Kmetz P.J., Wells T.N.C., Groot P.H.E., Saxty B.A., Hughes S.A., Franklin M., Gloger I.S. Eur. J. Biochem. 204:491-499(1992)

Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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