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ACPP protein :: Prostatic Acid Phosphatase Protein

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Catalog # MBS173168
Unit / Price
  100 Units  /  $140 +1 FREE 8GB USB
  1000 Units  /  $290 +1 FREE 8GB USB
  10000 Units  /  $1,850 +2 FREE 8GB USB
ACPP protein
Product Name

Prostatic Acid Phosphatase (ACPP), Protein

Popular Item
Also Known As

Prostatic Acid Phosphatase (PAP/ACP), Human

Product Synonym Names
ACP; PAP; Acid Phos; 5'-nucleotidase; 5'-NT; Ecto-5'-nucleotidase; Thiamine monophosphatase; TMPase; PAPf39; Prostatic Acid Phosphatase (ACP, PAP), Human Semen - Lyophilized
Product Gene Name
Product Synonym Gene Name
5'-NT; ACP-3; ACP3; PAP[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Length
423
OMIM
gene 200950
3D Structure
ModBase 3D Structure for P11117
Purity/Purification
Partially Purified
Form/Format
Lyophilized
Appearance: Off-white powder
Source
Human Semen
EC Number
3.1.3.2
Unit Definition
One unit will catalyze the hydrolysis of one micromole of thymolphthalein monophosphate to thymolphthalein and phosphate per minute at pH 5.6 and 37 degree C.
Specific Activity
Typically >= 30 U/mg protein
Solubility
Clear, colorless solution (10 mg/mL saline)
Recertification
3 years
Protein
>= 0.2 protein/mg (Coomassie/Biuret)
CAS Number
9001-77-8
Activity
5 - 15 U/mg solid (Dimension Clinical Chemistry System)
Preparation and Storage
At -20 degree C
Other Notes
Small volumes of ACPP protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
ACPP protein
MyBioSource produces human Prostatic Acid Phosphatase (PAP/ACP) for research,life science and diagnostic manufacturing uses.

Custom preparations, technical support, bulk quantities and aliquoting available.

What is Human Acid Phosphatase? Human Prostate Acid Phosphatase also known as human prostatic acid phosphatase (PAP,ACP) is alternative marker to Prostate Specific Antigen (PSA) for prostate malignancy. Rape investigations will often include testing for the presence of Human prostatic (prostate) acid phosphatase in vaginal fluid.

The highest levels of acid phosphatase are found in metastasized prostate cancer. Diseases of the bone, such as Paget's disease or hyperparathyroidism, diseases of blood cells, such as sickle-cell disease or multiple myeloma or lysosomal storage diseases, such as Gaucher's disease, will show moderately increased levels.

Human Prostate Acid Phosphatase also known as human prostatic acid phosphatase (PAP, ACP) is alternative marker to prostate specific antigen (PSA) for prostate malignancy. Rape investigations will often include testing for the presence of Human prostatic (prostate) acid phosphatase in vaginal fluid.

Human prostatic Acid phosphatase (PAP) is a phosphatase, a type of enzyme, used to free attached phosphate groups from other molecules during digestion. Acid Phosphatase is stored in lysosomes and functions when these fuse with endosomes, which are acidified while they function; therefore,Human Acid Phosphatase has an acid pH optimum below 7.0.
NCBI/Uniprot data below describe general gene information for ACPP. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
~100,000
NCBI Official Full Name
acid phosphatase
NCBI Official Synonym Full Names
acid phosphatase 2, lysosomal
NCBI Official Symbol
NCBI Official Synonym Symbols
NCBI Protein Information
lysosomal acid phosphatase
UniProt Protein Name
Lysosomal acid phosphatase
UniProt Gene Name
UniProt Synonym Gene Names
UniProt Entry Name
PPAL_HUMAN
NCBI Summary for ACPP
This gene encodes the beta subunit of lysosomal acid phosphatase (LAP). LAP is chemically and genetically distinct from red cell acid phosphatase. The encoded protein belongs to a family of distinct isoenzymes which hydrolyze orthophosphoric monoesters to alcohol and phosphate. LAP-deficiencies in mice cause multiple defects including bone structure alterations, lysosomal storage defects in the kidneys and central nervous system, and an increased tendency towards seizures. An enzymatically-inactive allele of LAP in mice exhibited a more severe phenotype than the null allele, and defects included cerebellum abnormalities, growth retardation, hair-follicle abnormalities, and an ataxia-like phenotype. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]
UniProt Comments for ACPP
ACP2: Defects in ACP2 are a cause of acid phosphatase deficiency (ACPHD). The clinical features are intermittent vomiting, hypotonia, lethargy, opisthotonos, terminal bleeding, and death in early infancy. Lysosomal acid phosphatase is deficient in cultured fibroblasts and multiple tissues. Belongs to the histidine acid phosphatase family.

Protein type: EC 3.1.3.2; Motility/polarity/chemotaxis; Phosphatase (non-protein); Cofactor and Vitamin Metabolism - riboflavin; Membrane protein, integral

Chromosomal Location of Human Ortholog: 11p11.2|11p12-p11

Cellular Component: lysosomal lumen; membrane; lysosomal membrane; lysosome; integral to membrane

Molecular Function: acid phosphatase activity

Biological Process: dephosphorylation; lysosome organization and biogenesis; skeletal development

Disease: Acid Phosphatase Deficiency
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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