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ACSL4 cdna clone

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Catalog # MBS1270741
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  0.01 mg Plasmid + 0.2 mL Glycerol-Stock  /  $390 +1 FREE 8GB USB
ACSL4 cdna clone
Product Name

ACSL4, cDNA Clone

Popular Item
Full Product Name

ACSL4 cDNA Clone

Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atggcaaaga gaataaaagc taagcccact tcagacaaac ctggaagtcc atatcgctct gtcacacact tcgactcact agctgtaata gacatccctg gagcagatac tctggataaa ttatttgacc atgctgtatc caagtttggg aagaaggaca gccttgggac cagggaaatc ctaagtgaag aaaatgaaat gcagccaaat ggaaaagttt ttaagaagtt aattcttggg aattataaat ggatgaacta tcttgaagtg aatcgcagag tgaataactt tggtagtgga ctcactgcac tgggactaaa accaaagaac accattgcca tcttctgtga gaccagggcc gaatggatga ttgcagcaca gacctgcttt aagtacaact ttcctcttgt gactttatat gccacacttg gcaaagaagc agtagttcat gggctaaatg aatctgaggc ttcctatctg attaccagtg ttgaacttct ggaaagtaaa cttaagactg cattgttaga tatcagttgt gttaaacata tcatttatgt ggacaataag gctatcaata aagcagagta ccctgaagga tttgagattc acagcatgca atcagtagaa gagttgggat ctaacccaga aaacttgggc attcctccaa gtagaccaac gccttcagac atggccattg ttatgtatac tagtggttct actggccgac ctaagggagt gatgatgcat catagcaatt tgatagctgg aatgacaggc cagtgtgaaa gaatacctgg actgggaccg aaggacacat atattggcta cttgcctttg gctcatgtgc tagaactgac agcagagata tcttgcttta cctatggctg caggattgga tattcttctc cgcttacact ctctgaccag tccagcaaaa ttaaaaaagg aagcaaagga gactgtactg tactgaagcc cacacttatg gctgctgttc cggaaatcat ggatagaatt tataagaatg ttatgagcaa agtccaagag atgaattata ttcagaaaac tctgttcaag atagggtatg attacaaatt ggaacagatc aaaaagggat atgatgcacc tctttgcaat ctgttactgt ttaaaaaggt caaggccctg ctgggaggga atgtccgcat gatgctgtct ggaggggccc cgctatctcc tcagacacac cgattcatga atgtctgctt ctgctgccca attggccagg gttatggact gacagaatca tgtggtgctg ggacagttac tgaagtaact gactatacta ctggcagagt tggagcacct cttatttgct gtgaaattaa gctaaaagac tggcaagaag gcggttatac aattaatgac aagccaaacc ccagaggtga aatcgtaatt ggtggacaga acatctccat gggatatttt aaaaatgaag agaaaacagc agaagattat tctgtggatg aaaatggaca aaggtggttt tgcactggtg atattggaga attccatccc gatggatgtt tacagattat agatcgtaag aaagatctag tgaagttaca agcaggagag tatgtatctc ttgggaaagt ggaagctgca ctgaagaatt gtccacttat tgacaacatc tgtgcttttg ccaaaagtga tcagtcctat gtgatcagtt ttgtggttcc taaccagaaa aggttgacac ttttggcaca acagaaaggg gtagaaggaa cttgggttga tatctgcaat aatcctgcta tggaagctga aatactgaaa gaaattcgag aagctgcaaa tgccatgaaa ttggagcgat ttgaaattcc aatcaaggtt cgattaagcc cagagccatg gacccctgaa actggtttgg taactgatgc tttcaaactg aaaaggaagg agctgaggaa ccattacctc aaagacattg aacgaatgta tgggggcaaa taa
OMIM
300157
Vector
pENTR223.1 or pUC
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of ACSL4 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for ACSL4. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
74,436 Da
NCBI Official Full Name
Homo sapiens acyl-CoA synthetase long-chain family member 4, mRNA
NCBI Official Synonym Full Names
acyl-CoA synthetase long-chain family member 4
NCBI Official Symbol
ACSL4  [Similar Products]
NCBI Official Synonym Symbols
ACS4; FACL4; LACS4; MRX63; MRX68
  [Similar Products]
NCBI Protein Information
long-chain-fatty-acid--CoA ligase 4
UniProt Protein Name
Long-chain-fatty-acid--CoA ligase 4
UniProt Synonym Protein Names
Long-chain acyl-CoA synthetase 4; LACS 4
UniProt Gene Name
ACSL4  [Similar Products]
UniProt Synonym Gene Names
ACS4; FACL4; LACS4; LACS 4  [Similar Products]
UniProt Entry Name
ACSL4_HUMAN
NCBI Summary for ACSL4
The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme preferentially utilizes arachidonate as substrate. The absence of this enzyme may contribute to the mental retardation or Alport syndrome. Alternative splicing of this gene generates multiple transcript variants. [provided by RefSeq, Jan 2016]
UniProt Comments for ACSL4
ACSL4: Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses arachidonate and eicosapentaenoate as substrates. Defects in ACSL4 are the cause of mental retardation X- linked type 63 (MRX63). Mental retardation is a mental disorder characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Non- syndromic mental retardation patients do not manifest other clinical signs. Defects in ACSL4 are involved in Alport syndrome with mental retardation midface hypoplasia and elliptocytosis (ATS-MR). A X-linked contiguous gene deletion syndrome characterized by glomerulonephritis, deafness, mental retardation, midface hypoplasia and elliptocytosis. Belongs to the ATP-dependent AMP-binding enzyme family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Lipid Metabolism - fatty acid; Membrane protein, integral; Ligase; EC 6.2.1.3

Chromosomal Location of Human Ortholog: Xq22.3-q23

Cellular Component: cytoplasm; endoplasmic reticulum membrane; lipid particle; membrane

Molecular Function: arachidonate-CoA ligase activity; long-chain-fatty-acid-CoA ligase activity; very-long-chain-fatty-acid-CoA ligase activity

Biological Process: lipid metabolic process

Disease: Mental Retardation, X-linked 63
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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