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ACTL6A recombinant protein :: Actin-like protein 6A (ACTL6A) Recombinant Protein

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Catalog # MBS1100884
Unit / Price
Scan QR to view Datasheet
  0.05 mg (E-Coli)  /  $845 +1 FREE 8GB USB
  0.05 mg (Yeast)  /  $925 +1 FREE 8GB USB
  0.2 mg (E-Coli)  /  $1,130 +1 FREE 8GB USB
  0.05 mg (Baculovirus)  /  $1,155 +1 FREE 8GB USB
  0.5 mg (E-Coli)  /  $1,245 +1 FREE 8GB USB
  0.2 mg (Yeast)  /  $1,250 +1 FREE 8GB USB
  0.05 mg (Mammalian-Cell)  /  $1,395 +1 FREE 8GB USB
  0.5 mg (Yeast)  /  $1,415 +1 FREE 8GB USB
  0.1 mg (Baculovirus)  /  $1,665 +2 FREE 8GB USB
  1 mg (E-Coli)  /  $1,885 +2 FREE 8GB USB
  0.5 mg (Baculovirus)  /  $2,165 +2 FREE 8GB USB
  1 mg (Yeast)  /  $2,245 +2 FREE 8GB USB
  0.1 mg (Mammalian-Cell)  /  $2,255 +2 FREE 8GB USB
  1 mg (Baculovirus)  /  $3,345 +4 FREE 8GB USB
ACTL6A recombinant protein
Product Name

Actin-like protein 6A (ACTL6A), Recombinant Protein

Full Product Name

Recombinant Human Actin-like protein 6A (ACTL6A)

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
2-429aa, Full Length of Mature Protein
Sequence
SGGVYGGDEV GALVFDIGSY TVRAGYAGED CPKVDFPTAI GMVVERDDGS TLMEIDGDKG KQGGPTYYID TNALRVPREN MEAISPLKNG MVEDWDSFQA ILDHTYKMHV KSEASLHPVL MSEAPWNTRA KREKLTELMF EHYNIPAFFL CKTAVLTAFA NGRSTGLILD SGATHTTAIP VHDGYVLQQG IVKSPLAGDF ITMQCRELFQ EMNIELVPPY MIASKEAVRE GSPANWKRKE KLPQVTRSWH NYMCNCVIQD FQASVLQVSD STYDEQVAAQ MPTVHYEFPN GYNCDFGAER LKIPEGLFDP SNVKGLSGNT MLGVSHVVTT SVGMCDIDIR PGLYGSVIVA GGNTLIQSFT DRLNRELSQK TPPSMRLKLI ANNTTVERRF SSWIGGSILA SLGTFQQMWI SKQEYEEGGK QCVERKCP
OMIM
604958
3D Structure
ModBase 3D Structure for O96019
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Human
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of ACTL6A recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
ACTL6A recombinant protein
This gene encodes a family member of actin-related proteins (ARPs), which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene encodes a 53 kDa subunit protein of the BAF (BRG1
brm-associated factor) complex in mammals, which is functionally related to SWI
SNF complex in S. cerevisiae and Drosophila; the latter is thought to facilitate transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. Together with beta-actin, it is required for maximal ATPase activity of BRG1, and for the association of the BAF complex with chromatin
matrix. Three transcript variants that encode two different protein isoforms have been described.
NCBI/Uniprot data below describe general gene information for ACTL6A. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
43,236 Da
NCBI Official Full Name
actin-like protein 6A isoform 1
NCBI Official Synonym Full Names
actin like 6A
NCBI Official Symbol
ACTL6A  [Similar Products]
NCBI Official Synonym Symbols
Arp4; ACTL6; BAF53A; INO80K; ARPN-BETA
  [Similar Products]
NCBI Protein Information
actin-like protein 6A
UniProt Protein Name
Actin-like protein 6A
UniProt Synonym Protein Names
53 kDa BRG1-associated factor A; Actin-related protein Baf53a; ArpNbeta; BRG1-associated factor 53A; BAF53A; INO80 complex subunit K
Protein Family
UniProt Gene Name
ACTL6A  [Similar Products]
UniProt Synonym Gene Names
BAF53; BAF53A; INO80K; BAF53A  [Similar Products]
NCBI Summary for ACTL6A
This gene encodes a family member of actin-related proteins (ARPs), which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene encodes a 53 kDa subunit protein of the BAF (BRG1/brm-associated factor) complex in mammals, which is functionally related to SWI/SNF complex in S. cerevisiae and Drosophila; the latter is thought to facilitate transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. Together with beta-actin, it is required for maximal ATPase activity of BRG1, and for the association of the BAF complex with chromatin/matrix. Three transcript variants that encode two different protein isoforms have been described. [provided by RefSeq, Jul 2008]
UniProt Comments for ACTL6A
Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Required for maximal ATPase activity of SMARCA4/BRG1/BAF190A and for association of the SMARCA4/BRG1/BAF190A containing remodeling complex BAF with chromatin/nuclear matrix. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neural progenitors. During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (). Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Putative core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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