BC014610
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
48,644 Da
NCBI Official Full Name
Homo sapiens actin-like 7A, mRNA
NCBI Official Synonym Full Names
actin like 7A
NCBI Protein Information
actin-like protein 7A
UniProt Protein Name
Actin-like protein 7A
UniProt Synonym Protein Names
Actin-like-7-alpha
UniProt Entry Name
ACL7A_HUMAN
NCBI Summary for ACTL7A
The protein encoded by this gene is a member of a family of actin-related proteins (ARPs) which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene (ACTL7A), and related gene, ACTL7B, are intronless, and are located approximately 4 kb apart in a head-to-head orientation within the familial dysautonomia candidate region on 9q31. Based on mutational analysis of the ACTL7A gene in patients with this disorder, it was concluded that it is unlikely to be involved in the pathogenesis of dysautonomia. The ACTL7A gene is expressed in a wide variety of adult tissues, however, its exact function is not known. [provided by RefSeq, Jul 2008]
UniProt Comments for ACTL7A
AL7A: an actin-related protein (ARP). Shares significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. Its gene (ACTL7A), and a related gene, ACTL7B, are intronless. Expressed in a wide variety of adult tissues, however, its exact function is not known.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 9q31
Cellular Component: cytoplasm; Golgi apparatus; nucleus; protein complex
Molecular Function: protein binding; structural constituent of cytoskeleton
Research Articles on ACTL7A
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Diseases associated with ACTL7A cdna clone
Organs/Tissues associated with ACTL7A cdna clone
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