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ACTN2 elisa kit :: Bovine Actinin Alpha 2 ELISA Kit

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Catalog # MBS009455
Unit / Price
  48-Strip-Wells  /  $470 +1 FREE 8GB USB
  96-Strip-Wells  /  $680 +1 FREE 8GB USB
  5x96-Strip-Wells  /  $3,100 +3 FREE 8GB USB
  10x96-Strip-Wells  /  $6,095 +7 FREE 8GB USB
ACTN2 elisa kit
Product Name

Actinin Alpha 2 (ACTN2), ELISA Kit

Full Product Name

Bovine Actinin Alpha 2 ELISA Kit

Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Request for Current Manual Insert
Chromosome Location
Chromosome: 1; NC_000001.10 (236849770..236927558). Location: 1q42-q43
OMIM
102573
3D Structure
ModBase 3D Structure for P35609
Species Reactivity
Assay Type
Sandwich
Preparation and Storage
Store all reagents at 2-8 degree C
Product Note
Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
Other Notes
Small volumes of ACTN2 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Searchable Terms forACTN2purchase
MBS009455 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Actinin Alpha 2 (ACTN2) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing ACTN2. The ELISA analytical biochemical technique of the MBS009455 kit is based on ACTN2 antibody-ACTN2 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect ACTN2 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, ACTN2. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
NCBI/Uniprot data below describe general gene information for ACTN2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
103,854 Da
NCBI Official Full Name
alpha-actinin-2 isoform 3
NCBI Official Synonym Full Names
actinin, alpha 2
NCBI Official Symbol
ACTN2  [Similar Products]
NCBI Official Synonym Symbols
CMD1AA
  [Similar Products]
NCBI Protein Information
alpha-actinin-2; F-actin cross-linking protein; alpha-actinin skeletal muscle
UniProt Protein Name
Alpha-actinin-2
UniProt Synonym Protein Names
Alpha-actinin skeletal muscle isoform 2; F-actin cross-linking protein
Protein Family
UniProt Gene Name
ACTN2  [Similar Products]
UniProt Entry Name
ACTN2_HUMAN
NCBI Summary for ACTN2
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a muscle-specific, alpha actinin isoform that is expressed in both skeletal and cardiac muscles. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2013]
UniProt Comments for ACTN2
ACTN2: F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. Defects in ACTN2 are the cause of cardiomyopathy dilated type 1AA (CMD1AA). Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. Belongs to the alpha-actinin family.

Protein type: Cytoskeletal; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 1q42-q43

Cellular Component: cortical actin cytoskeleton; cytoskeleton; focal adhesion; dendritic spine; extracellular region; actin filament; pseudopodium; cytosol; Z disc; filopodium

Molecular Function: actin filament binding; integrin binding; protein dimerization activity; identical protein binding; protein binding; LIM domain binding; structural constituent of muscle; cytoskeletal protein binding; titin binding; calcium ion binding; FATZ binding; thyroid hormone receptor coactivator activity

Biological Process: regulation of apoptosis; focal adhesion formation; synaptic transmission; platelet activation; regulation of membrane potential; platelet degranulation; negative regulation of potassium ion transport; microspike biogenesis; positive regulation of potassium ion transport; cell adhesion; blood coagulation; muscle filament sliding; protein homotetramerization

Disease: Cardiomyopathy, Dilated, 1aa
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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