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ADA native protein :: Adenosine Deaminase Native Protein

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Catalog # MBS170503
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ADA native protein
Product Name

Adenosine Deaminase (ADA), Native Protein

Also Known As

Adenosine Deaminase - Calf Spleen

Product Synonym Names
ADA; adenosine aminohydrolase
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Length
363
OMIM
102700
3D Structure
ModBase 3D Structure for P00813
Host
Calf Spleen
Purity/Purification
Purified
Form/Format
Lyophilized
Protein
Reported in mg protein/mg solid
CAS Number
9026-93-1
E.C. Number
3.5.4.4
Attribute Unit-definition
One Unit converts one micromole of adenosine to inosine per minute at 25 degree C, pH 7.4.
Preparation and Storage
Store at 2-8 degree C
Other Notes
Small volumes of ADA native protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for ADA. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
40,764 Da[Similar Products]
NCBI Official Full Name
adenosine deaminase
NCBI Official Synonym Full Names
adenosine deaminase
NCBI Official Symbol
NCBI Protein Information
adenosine deaminase
UniProt Protein Name
Adenosine deaminase
UniProt Synonym Protein Names
Adenosine aminohydrolase
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
UniProt Entry Name
ADA_HUMAN
NCBI Summary for ADA
This gene encodes an enzyme that catalyzes the hydrolysis of adenosine to inosine. Various mutations have been described for this gene and have been linked to human diseases. Deficiency in this enzyme causes a form of severe combined immunodeficiency disease (SCID), in which there is dysfunction of both B and T lymphocytes with impaired cellular immunity and decreased production of immunoglobulins, whereas elevated levels of this enzyme have been associated with congenital hemolytic anemia. [provided by RefSeq, Jul 2008]
UniProt Comments for ADA
ADA: a enzyme that converts adenosine + H2O into inosine + NH3. Found in all tissues, occurs in large amounts in T-lymphocytes and, at the time of weaning, in gastrointestinal tissues. Genetic ADA deficiencies are a cause of autosomal recessive severe combined immuno-deficiency (SCID). Hereditary hemolytic anemia is caused by expression levels in erythrocytes 50-70 times greater than the norm.

Protein type: Hydrolase; Nucleotide Metabolism - purine; EC 3.5.4.4

Chromosomal Location of Human Ortholog: 20q13.12

Cellular Component: cell surface; cytoplasm; cytosol; external side of plasma membrane; lysosome; membrane; plasma membrane

Molecular Function: adenosine deaminase activity; protein binding; zinc ion binding

Biological Process: adenosine catabolic process; hypoxanthine salvage; inosine biosynthetic process; negative regulation of adenosine receptor signaling pathway; purine nucleotide salvage; purine salvage; regulation of cell-cell adhesion mediated by integrin; response to hypoxia; T cell activation

Disease: Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-negative, B Cell-negative, Nk Cell-negative, Due To Adenosine Deaminase Deficiency
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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