Options Full Datasheet Printer Friendly Datasheet Prepare for Printing Full Datasheet Printer Friendly Datasheet Prepare for Printing Have Questions? Ask Us! Request A Quote Today! Add To Compare List ADAM10 elisa kit :: Bovine A Disintegrin and Metalloprotease 10 ELISA Kit Catalog # MBS015604 Unit / Price 48-Strip-Wells / $470 +1 FREE 8GB USB 96-Strip-Wells / $680 +1 FREE 8GB USB 5x96-Strip-Wells / $3,100 +3 FREE 8GB USB 10x96-Strip-Wells / $6,095 +7 FREE 8GB USB Product Name Product Info Accession #s Product Desc Diseases/Tissues/Pathways Applications References Product Name A Disintegrin and Metalloprotease 10 (ADAM10), ELISA Kit Popular Item Full Product Name Bovine A Disintegrin and Metalloprotease 10 ELISA Kit Product Gene Name ADAM10 elisa kit[Similar Products] Research Use Only For Research Use Only. Not for use in diagnostic procedures. TOP Request for Current Manual Insert Request Current Manual Chromosome Location Chromosome: 15; NC_000015.9 (58888510..59042177, complement). Location: 15q22 OMIM 602192 3D Structure ModBase 3D Structure for O14672 Species Reactivity Bovine Assay Type Sandwich Preparation and Storage Store all reagents at 2-8 degree C Product Note Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual. Other Notes Small volumes of ADAM10 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply. Searchable Terms forADAM10purchase MBS015604 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the A Disintegrin and Metalloprotease 10 (ADAM10) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing ADAM10. The ELISA analytical biochemical technique of the MBS015604 kit is based on ADAM10 antibody-ADAM10 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect ADAM10 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, ADAM10. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%). TOP NCBI/Uniprot data below describe general gene information for ADAM10. It may not necessarily be applicable to this product. NCBI GI # 2393947 NCBI GeneID 102 NCBI Accession # AAC51766.1 [Other Products] UniProt Primary Accession # O14672 [Other Products] UniProt Secondary Accession # Q10742; Q92650[Other Products] UniProt Related Accession # O14672[Other Products] Molecular Weight 84,142 Da TOP NCBI Official Full Name ADAM10 NCBI Official Synonym Full Names ADAM metallopeptidase domain 10 NCBI Official Symbol ADAM10 [Similar Products] NCBI Official Synonym Symbols kuz; AD10; MADM; CD156c; HsT18717 [Similar Products] NCBI Protein Information disintegrin and metalloproteinase domain-containing protein 10; CDw156; ADAM 10; kuzbanian protein homolog; mammalian disintegrin-metalloprotease; a disintegrin and metalloprotease domain 10; a disintegrin and metalloproteinase domain 10 UniProt Protein Name Disintegrin and metalloproteinase domain-containing protein 10 UniProt Synonym Protein Names CDw156; Kuzbanian protein homolog; Mammalian disintegrin-metalloprotease Protein Family Disintegrin and metalloproteinase domain-containing protein UniProt Gene Name ADAM10 [Similar Products] UniProt Synonym Gene Names KUZ; MADM; ADAM 10 [Similar Products] UniProt Entry Name ADA10_HUMAN TOP NCBI Summary for ADAM10 Members of the ADAM family are cell surface proteins with a unique structure possessing both potential adhesion and protease domains. This gene encodes and ADAM family member that cleaves many proteins including TNF-alpha and E-cadherin. [provided by RefSeq, Jul 2008] TOP UniProt Comments for ADAM10 ADAM10: Cleaves the membrane-bound precursor of TNF-alpha at '76-Ala-|-Val-77' to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth- like factor, ephrin-A2 and for constitutive and regulated alpha- secretase cleavage of amyloid precursor protein (APP). Contributes to the normal cleavage of the cellular prion protein. Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity. Controls also the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis. Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10-processed FasL (FasL APL) transmembrane form. Also cleaves the ectodomain of the integral membrane proteins CORIN and ITM2B. May regulate the EFNA5-EPHA3 signaling.Protein type: Membrane protein, integral; Motility/polarity/chemotaxis; EC 3.4.24.81; Cell adhesion; Vesicle; Cell surface; ProteaseChromosomal Location of Human Ortholog: 15q22Cellular Component: Golgi apparatus; cell surface; focal adhesion; intracellular membrane-bound organelle; membrane; postsynaptic density; cytoplasm; integral to membrane; plasma membrane; Golgi-associated vesicle; nucleusMolecular Function: integrin binding; protein binding; protein homodimerization activity; metallopeptidase activity; zinc ion binding; metalloendopeptidase activity; endopeptidase activity; SH3 domain binding; protein kinase binding; receptor bindingBiological Process: epidermal growth factor receptor signaling pathway; integrin-mediated signaling pathway; axon guidance; Notch signaling pathway; extracellular matrix organization and biogenesis; in utero embryonic development; constitutive protein ectodomain proteolysis; membrane protein ectodomain proteolysis; Notch receptor processing; negative regulation of cell adhesion; protein amino acid phosphorylation; positive regulation of cell growth; collagen catabolic process; extracellular matrix disassembly; PMA-inducible membrane protein ectodomain proteolysis; cell-cell signaling; monocyte activation; positive regulation of cell proliferation; ephrin receptor signaling pathway; positive regulation of cell migrationDisease: Reticulate Acropigmentation Of Kitamura; Alzheimer Disease 18 Research Articles on ADAM10 1. MiR-144 and Mir-451 negatively regulator the ADAM10 protein expression and may contribute to Alzheimer disease pathogenesis. TOP Precautions All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines. Disclaimer While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information. TOP Products associated withADAM10 elisa kit Reference Product PubMed Publications ADAM17 elisa kit >187 publications with ADAM10 and ADAM17 EGFR elisa kit >25 publications with ADAM10 and EGFR ADAM12 elisa kit >24 publications with ADAM10 and ADAM12 CTNNB1 elisa kit >13 publications with ADAM10 and CTNNB1 NOTCH1 elisa kit >12 publications with ADAM10 and NOTCH1 CDH2 elisa kit >5 publications with ADAM10 and CDH2 DLL1 elisa kit >2 publications with ADAM10 and DLL1 Pathways associated with ADAM10 elisa kit Products by Pathway Pathway Diagram Activated NOTCH1 Transmits Signal To The Nucleus Pathway antibodies Activated NOTCH1 Transmits Signal To The Nucleus Pathway Diagram Alzheimer's Disease Pathway antibodies Alzheimer's Disease Pathway Diagram Alzheimer's Disease Pathway antibodies Alzheimer's Disease Pathway Diagram Alzheimers Disease Pathway antibodies Alzheimers Disease Pathway Diagram Constitutive Signaling By NOTCH1 HD Domain Mutants Pathway antibodies Constitutive Signaling By NOTCH1 HD Domain Mutants Pathway Diagram Constitutive Signaling By NOTCH1 HD+PEST Domain Mutants Pathway antibodies Constitutive Signaling By NOTCH1 HD+PEST Domain Mutants Pathway Diagram Constitutive Signaling By NOTCH1 PEST Domain Mutants Pathway antibodies Constitutive Signaling By NOTCH1 PEST Domain Mutants Pathway Diagram Constitutive Signaling By NOTCH1 T(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Pathway antibodies Constitutive Signaling By NOTCH1 T(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Pathway Diagram Degradation Of Collagen Pathway antibodies Degradation Of Collagen Pathway Diagram Degradation Of The Extracellular Matrix Pathway antibodies Degradation Of The Extracellular Matrix Pathway Diagram Diseases associated with ADAM10 elisa kit Disease Name Pubmed Publications Necrosis Antibodies >179 publications with ADAM10 and Necrosis Neoplasms Antibodies >118 publications with ADAM10 and Neoplasms Brain Diseases Antibodies >101 publications with ADAM10 and Brain Diseases Inflammation Antibodies >45 publications with ADAM10 and Inflammation Skin Diseases Antibodies >27 publications with ADAM10 and Skin Diseases Kidney Diseases Antibodies >17 publications with ADAM10 and Kidney Diseases Cardiovascular Diseases Antibodies >16 publications with ADAM10 and Cardiovascular Diseases Breast Neoplasms Antibodies >16 publications with ADAM10 and Breast Neoplasms Neoplasm Metastasis Antibodies >15 publications with ADAM10 and Neoplasm Metastasis Vascular Diseases Antibodies >15 publications with ADAM10 and Vascular Diseases Organs/Tissues associated with ADAM10 elisa kit Organ/Tissue Name Pubmed Publications Brain Antibodies >129 publications with ADAM10 and Brain Blood Antibodies >88 publications with ADAM10 and Blood Vascular Antibodies >40 publications with ADAM10 and Vascular Kidney Antibodies >36 publications with ADAM10 and Kidney Embryonic Tissue Antibodies >32 publications with ADAM10 and Embryonic Tissue Muscle Antibodies >25 publications with ADAM10 and Muscle Nerve Antibodies >22 publications with ADAM10 and Nerve Skin Antibodies >20 publications with ADAM10 and Skin Bone Antibodies >18 publications with ADAM10 and Bone Lung Antibodies >17 publications with ADAM10 and Lung TOP © 2006-18 MyBioSource.com. 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