• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

ADAM22 recombinant protein :: A Disintegrin And Metalloprotease 22 Recombinant Protein

Scan QR to view Datasheet
Catalog # MBS2033170 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Unit / Price
  0.01 mg  /  $135 +1 FREE 8GB USB
  0.05 mg  /  $250 +1 FREE 8GB USB
  0.1 mg  /  $385 +1 FREE 8GB USB
  0.2 mg  /  $470 +1 FREE 8GB USB
  0.5 mg  /  $910 +1 FREE 8GB USB
  1 mg  /  $1,345 +1 FREE 8GB USB
SDS-Page
Product Name

A Disintegrin And Metalloprotease 22 (ADAM22), Recombinant Protein

Also Known As

Recombinant A Disintegrin And Metalloprotease 22 (ADAM22)

Product Synonym Names
MDC2; Disintegrin And Metalloproteinase Domain-Containing Protein 22; Metalloproteinase-Like,Disintegrin-Like,And Cysteine-Rich Protein 2
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Length
342
Sequence
L AQSLAHNIGI ISDKRKLASG ECKCEDTWSG CIMGDTGYYL PKKFTQCNIE EYHDFLNSGG GACLFNKPSK LLDPPECGNG FIETGEECDC GTPAECVLEG AECCKKCTLT QDSQCSDGLC CKKCKFQPMG TVCREAVNDC DIRETCSGNS SQCAPNIHKM DGYSCDGVQG ICFGGRCKTR DRQCKYIWGQ KVTASDKYCY EKLNIEGTEK GN
OMIM
603709
Host
E Coli
Purity/Purification
> 95%
Form/Format
Supplied as lyophilized form in PBS, pH7.4, containing 5% trehalose, 0.01% sarcosyl.
Predicted Molecular Mass
27.0kDa
Usage
Reconstitute in sterile PBS, pH7.2-pH7.4.
Endotoxin Level
<1.0EU per 1 ug (determined by the LAL method)
Expression System
Prokaryotic expression
Fragment
Leu370~Asn582
Organism Species
Human
Tag
two N-terminal Tags, His-tag and T7-tag
Preparation and Storage
Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months.
Stability Test: The thermal stability is described by the loss rate of the target protein. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. (Referring from China Biological Products Standard, which was calculated by the Arrhenius equation.) The loss of this protein is lessthan 5% within the expiration date under appropriate storage condition.
Other Notes
Small volumes of ADAM22 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for ADAM22 recombinant protein
SDS-PAGE, Western (WB), ELISA (EIA), Immunoprecipitation (IP).

NCBI/Uniprot data below describe general gene information for ADAM22. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
96,637 Da
NCBI Official Full Name
ADAM22 protein
NCBI Official Synonym Full Names
ADAM metallopeptidase domain 22
NCBI Official Symbol
ADAM22  [Similar Products]
NCBI Official Synonym Symbols
MDC2; ADAM 22
  [Similar Products]
NCBI Protein Information
disintegrin and metalloproteinase domain-containing protein 22
UniProt Protein Name
Disintegrin and metalloproteinase domain-containing protein 22
UniProt Synonym Protein Names
Metalloproteinase-disintegrin ADAM22-3; Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 2
UniProt Gene Name
ADAM22  [Similar Products]
UniProt Synonym Gene Names
MDC2; ADAM 22  [Similar Products]
UniProt Entry Name
ADA22_HUMAN
NCBI Summary for ADAM22
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. Unlike other members of the ADAM protein family, the protein encoded by this gene lacks metalloprotease activity since it has no zinc-binding motif. This gene is highly expressed in the brain and may function as an integrin ligand in the brain. In mice, it has been shown to be essential for correct myelination in the peripheral nervous system. Alternative splicing results in several transcript variants.[provided by RefSeq, Dec 2010]
UniProt Comments for ADAM22
ADAM22: Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein. Involved in regulation of cell adhesion and spreading and in inhibition of cell proliferation. Neuronal receptor for LGI1. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Cell adhesion; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 7q21

Cellular Component: axon; integral to membrane; plasma membrane

Molecular Function: integrin binding; metalloendopeptidase activity; protein binding; zinc ion binding

Biological Process: adult locomotory behavior; cell adhesion; central nervous system development; myelination in the peripheral nervous system; negative regulation of cell adhesion; proteolysis
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Pathways associated with ADAM22 recombinant protein
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000