NP_055080.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
disintegrin and metalloproteinase domain-containing protein 28 isoform 1 preproprotein
NCBI Official Synonym Full Names
ADAM metallopeptidase domain 28
NCBI Official Synonym Symbols
MDCL; MDC-L; ADAM23; MDC-Lm; MDC-Ls; eMDCII; ADAM 28; eMDC II [Similar Products]
NCBI Protein Information
disintegrin and metalloproteinase domain-containing protein 28; metalloproteinase-like, disintegrin-like, and cysteine-rich protein-L; epididymal metalloproteinase-like, disintegrin-like, and cysteine-rich protein II; epididymial metalloproteinase-like, disintegrin-like, and cysteine-rich protein II
UniProt Protein Name
Disintegrin and metalloproteinase domain-containing protein 28
UniProt Synonym Protein Names
Epididymal metalloproteinase-like, disintegrin-like, and cysteine-rich protein II; eMDC II; Metalloproteinase-like, disintegrin-like, and cysteine-rich protein L
UniProt Synonym Gene Names
UniProt Entry Name
ADA28_HUMAN
NCBI Summary for ADAM28
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene is a lymphocyte-expressed ADAM protein. This gene is present in a gene cluster with other members of the ADAM family on chromosome 8. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
UniProt Comments for ADAM28
ADAM28: May play a role in the adhesive and proteolytic events that occur during lymphocyte emigration or may function in ectodomain shedding of lymphocyte surface target proteins, such as FASL and CD40L. May be involved in sperm maturation. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Motility/polarity/chemotaxis; EC 3.4.24.-; Membrane protein, integral; Protease
Chromosomal Location of Human Ortholog: 8p21.2
Cellular Component: integral to membrane; extracellular region; plasma membrane
Molecular Function: metallopeptidase activity; zinc ion binding; metalloendopeptidase activity
Biological Process: spermatogenesis; proteolysis
Research Articles on ADAM28
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Products associated with ADAM28 recombinant protein
Diseases associated with ADAM28 recombinant protein
Organs/Tissues associated with ADAM28 recombinant protein
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