NP_112219.3
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
62,530 Da
NCBI Official Full Name
A disintegrin and metalloproteinase with thrombospondin motifs 10 isoform 1 preproprotein
NCBI Official Synonym Full Names
ADAM metallopeptidase with thrombospondin type 1 motif, 10
NCBI Official Synonym Symbols
WMS; WMS1; ADAM-TS10; ADAMTS-10 [Similar Products]
NCBI Protein Information
A disintegrin and metalloproteinase with thrombospondin motifs 10; ADAM-TS 10; zinc metalloendopeptidase; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 10
UniProt Protein Name
A disintegrin and metalloproteinase with thrombospondin motifs 10
UniProt Synonym Gene Names
UniProt Entry Name
ATS10_HUMAN
NCBI Summary for ADAMTS10
This gene belongs to the ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin type-1 motifs) family of zinc-dependent proteases. ADAMTS proteases are complex secreted enzymes containing a prometalloprotease domain of the reprolysin type attached to an ancillary domain with a highly conserved structure that includes at least one thrombospondin type 1 repeat. They have been demonstrated to have important roles in connective tissue organization, coagulation, inflammation, arthritis, angiogenesis and cell migration. The product of this gene plays a major role in growth and in skin, lens, and heart development. It is also a candidate gene for autosomal recessive Weill-Marchesani syndrome. [provided by RefSeq, Jul 2008]
UniProt Comments for ADAMTS10
ADAMTS10: Metalloprotease that participate in microfibrils assembly. Microfibrils are extracellular matrix components occurring independently or along with elastin in the formation of elastic tissues. Defects in ADAMTS10 are the cause of Weill-Marchesani syndrome 1 (WMS1). WMS1 is a rare connective tissue disorder characterized by short stature, brachydactyly, joint stiffness, and eye abnormalities including microspherophakia, ectopia lentis, severe myopia and glaucoma.
Protein type: Protease; Secreted, signal peptide; Motility/polarity/chemotaxis; EC 3.4.24.-; Secreted
Chromosomal Location of Human Ortholog: 19p13.2
Cellular Component: extracellular matrix; microfibril
Molecular Function: protein binding; zinc ion binding; metalloendopeptidase activity
Biological Process: proteolysis
Disease: Weill-marchesani Syndrome 1
Research Articles on ADAMTS10
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Products associated with ADAMTS10 elisa kit
Pathways associated with ADAMTS10 elisa kit
Diseases associated with ADAMTS10 elisa kit
Organs/Tissues associated with ADAMTS10 elisa kit
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