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Adamts12 recombinant protein :: A disintegrin and metalloproteinase with thrombospondin motifs 12 (Adamts12) Recombinant Protein

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Catalog # MBS1329749
Unit / Price
Scan QR to view Datasheet
  0.5 mg (E-Coli)  /  $1,035 +1 FREE 8GB USB
  0.05 mg (Baculovirus)  /  $1,035 +1 FREE 8GB USB
  0.05 mg (Mammalian-Cell)  /  $1,265 +1 FREE 8GB USB
  0.5 mg (Yeast)  /  $1,265 +1 FREE 8GB USB
  1 mg (E-Coli)  /  $1,555 +1 FREE 8GB USB
  0.1 mg (Baculovirus)  /  $1,555 +1 FREE 8GB USB
  0.1 mg (Mammalian-Cell)  /  $2,015 +2 FREE 8GB USB
  1 mg (Yeast)  /  $2,015 +2 FREE 8GB USB
  0.5 mg (Baculovirus)  /  $2,050 +2 FREE 8GB USB
  1 mg (Baculovirus)  /  $2,835 +3 FREE 8GB USB
Adamts12 recombinant protein
Product Name

A disintegrin and metalloproteinase with thrombospondin motifs 12 (Adamts12), Recombinant Protein

Popular Item
Full Product Name

Recombinant Mouse A disintegrin and metalloproteinase with thrombospondin motifs 12 (Adamts12) , partial

Product Synonym Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
210-460, Partial, include the Cysteine switch motif and Peptidase M12B domain.
Sequence
PICGLKDSLD NSVKQELQRE KWERKTLRSR SLSRRSISKE RWVETLVVAD TKTVEYHGSE NVESYILTIM NMVTGLFHSP SIGNLVHIVV VRLILLEEEE QGLKIVHHAE KTLSSFCKWQ KSINPKSDLN PVHHDVAVLI TRKDICAGVN RPCETLGLSQ LSGMCQPHRS CNINEDSGLP LAFTIAHELG HSFGIQHDGK ENDCEPVGRH PYIMSQQIQY DPTPLTWSKC SKEYITRFLD RGRGFCLDDI P
3D Structure
ModBase 3D Structure for Q811B3
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Mouse
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of Adamts12 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
Adamts12 recombinant protein
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS-1) motif. Individual members of this family differ in the number of C-terminal TS-1 motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains eight TS-1 motifs. It may play roles in pulmonary cells during fetal development or in tumor processes through its proteolytic activity or as a molecule potentially involved in regulation of cell adhesion.
NCBI/Uniprot data below describe general gene information for Adamts12. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
18,843 Da
NCBI Official Full Name
A disintegrin and metalloproteinase with thrombospondin motifs 12 preproprotein
NCBI Official Synonym Full Names
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 12
NCBI Official Symbol
Adamts12  [Similar Products]
NCBI Official Synonym Symbols
AI605170; ADAMTS-12
  [Similar Products]
NCBI Protein Information
A disintegrin and metalloproteinase with thrombospondin motifs 12
UniProt Protein Name
A disintegrin and metalloproteinase with thrombospondin motifs 12
UniProt Gene Name
Adamts12  [Similar Products]
UniProt Synonym Gene Names
ADAM-TS 12; ADAM-TS12; ADAMTS-12  [Similar Products]
NCBI Summary for Adamts12
This gene encodes a member of "a disintegrin and metalloproteinase with thrombospondin motifs" (ADAMTS) family of multi-domain matrix-associated metalloendopeptidases that have diverse roles in tissue morphogenesis and pathophysiological remodeling, in inflammation and in vascular biology. The encoded preproprotein undergoes proteolytic processing to generate an active protease. Mice lacking the encoded protein exhibit increased angiogenic response and tumor invasion in different models of angiogenesis and, severe inflammation and delayed recovery when subjected to experimental conditions that induce colitis, endotoxic sepsis and pancreatitis. [provided by RefSeq, Jul 2016]
UniProt Comments for Adamts12
Metalloprotease that plays a role in the degradation of COMP (). Cleaves also alpha-2 macroglobulin and aggregan. Has anti-tumorigenic properties ().
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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