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ADAMTS2 recombinant protein :: A Disintegrin And Metalloproteinase With Thrombospondin 2 (ADAMTS2) Recombinant Protein

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Catalog # MBS2010506 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Unit / Price
  0.01 mg  /  $135 +1 FREE 8GB USB
  0.05 mg  /  $250 +1 FREE 8GB USB
  0.1 mg  /  $385 +1 FREE 8GB USB
  0.2 mg  /  $470 +1 FREE 8GB USB
  0.5 mg  /  $910 +1 FREE 8GB USB
  1 mg  /  $1,345 +1 FREE 8GB USB
SDS-Page
Product Name

A Disintegrin And Metalloproteinase With Thrombospondin 2 (ADAMTS2), Recombinant Protein

Popular Item
Full Product Name

Recombinant A Disintegrin And Metalloproteinase With Thrombospondin 2 (ADAMTS2)

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
The target protein is fused with N-terminal His-Tag, its sequence is listed below.
MGHHHHHHSG S-QLPGLHY SMNEQCRFDF GLGYMMCTAF RTFDPCKQLW CSHPDNPYFC KTKKGPPLDG TMCAPGKHCF KGHCIWLTPD ILKRDGNWGA WSPFGSCSRT CGTGVKFRTR QCDNPHPANG GRTCSGLAYD FQLCNSQDCP
Chromosome Location
Chromosome: 7; AC_000164.1 (1956352..2165242). Location: chromosome: 7
3D Structure
ModBase 3D Structure for P79331
Host
E Coli
Purity/Purification
> 95%
Form/Format
Supplied as lyophilized form in PBS,pH7.4, containing 5% sucrose, 0.01% sarcosyl.
Organism
Bos taurus; Bovine (Cattle)
Expression System
Prokaryotic expression
Residues
Gln474~Pro610 (Accession # P79331) with N-terminal His-Tag
Endotoxin Level
<1.0EU per 1ug (determined by the LAL method)
Reconstitution
Reconstitute in sterile PBS, pH7.2-pH7.4.
Preparation and Storage
Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months.
Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test,that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. (Referring from China Biological Products Standard,which was calculated by the Arrhenius equation.) The loss of this protein is lessthan 5% within the expiration date under appropriate storage condition.
ISO Certification
Manufactured in an ISO 9001:2008 and ISO 13485:2003 Certified Laboratory.
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Other Notes
Small volumes of ADAMTS2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
ADAMTS2 recombinant protein
About the Marker: Effective Size Range: 10kDa to 70kDa.
Protein bands: 10kDa, 14kDa, 18kDa, 22kDa, 26kDa, 33kDa, 44kDa and70kDa.
Double intensity bands: The 26kDa, 18kDa, 10kDa bands are at doubleintensity to make location and size approximation of proteins of interestquick and easy.
Ready-to-use: No need to heat, dilute or add reducing agents before use.
Applications Tested/Suitable for ADAMTS2 recombinant protein
SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP)

NCBI/Uniprot data below describe general gene information for ADAMTS2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Related Accession #
Molecular Weight
16.6kDa
NCBI Official Full Name
A disintegrin and metalloproteinase with thrombospondin motifs 2
NCBI Official Synonym Full Names
ADAM metallopeptidase with thrombospondin type 1 motif, 2<
NCBI Official Symbol
ADAMTS2  [Similar Products]
NCBI Protein Information
A disintegrin and metalloproteinase with thrombospondin motifs 2; pNPI; PC I-NP; ADAM-TS2; ADAMTS-2; ADAM-TS 2; procollagen I N-proteinase; procollagen N-endopeptidase; procollagen I/II amino propeptide-processing enzyme; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 2
UniProt Protein Name
A disintegrin and metalloproteinase with thrombospondin motifs 2
UniProt Synonym Protein Names
Procollagen I N-proteinase; PC I-NP; Procollagen I/II amino propeptide-processing enzyme; Procollagen N-endopeptidase
UniProt Gene Name
ADAMTS2  [Similar Products]
UniProt Synonym Gene Names
NPI; ADAM-TS 2; ADAM-TS2; ADAMTS-2; PC I-NP; pNPI  [Similar Products]
UniProt Entry Name
ATS2_BOVIN
UniProt Comments for ADAMTS2
Function: Cleaves the propeptides of type I and II collagen prior to fibril assembly. Does not act on type III collagen. May also play a role in development that is independent of its role in collagen biosynthesis.

Catalytic activity: Cleaves the N-propeptide of collagen chain alpha-1(I) at Pro-|-Gln and of alpha-1(II) and alpha-2(I) at Ala-|-Gln.

Cofactor: Binds 1 zinc ion per subunit

By similarity.

Subunit structure: May belong to a multimeric complex. Binds specifically to collagen type XIV.

Subcellular location: Secreted › extracellular space › extracellular matrix

By similarity.

Tissue specificity: Enzymatic activity is detected at high level in all type I collagen-rich tissues such as skin, bones, tendons and aorta and at low level in brain and thymus. The mRNA levels were disproportionately high in heart, liver, retina and muscle.

Domain: The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix.

Post-translational modification: The N-terminus is blocked.The precursor is cleaved by a furin endopeptidase

By similarity.Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion

By similarity.

Involvement in disease: Defects in ADAMTS2 are the cause of dermatosparaxis, a recessively inherited disorder characterized by severe skin fragility and biochemically by the presence in skin of procollagen incompletely processed at the N-terminus.

Sequence similarities: Contains 1 disintegrin domain.Contains 1 peptidase M12B domain.Contains 1 PLAC domain.Contains 4 TSP type-1 domains.

Caution: Has sometimes been referred to as ADAMTS3.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Organs/Tissues associated with ADAMTS2 recombinant protein
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