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ADAMTS2 recombinant protein :: A Disintegrin And Metalloproteinase With Thrombospondin 2 (ADAMTS2) Recombinant Protein

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Catalog # MBS2018814 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Unit / Price
  0.01 mg  /  $135 +1 FREE 8GB USB
  0.05 mg  /  $245 +1 FREE 8GB USB
  0.1 mg  /  $365 +1 FREE 8GB USB
  0.2 mg  /  $450 +1 FREE 8GB USB
  0.5 mg  /  $870 +1 FREE 8GB USB
  1 mg  /  $1,280 +1 FREE 8GB USB
SDS-Page
Product Name

A Disintegrin And Metalloproteinase With Thrombospondin 2 (ADAMTS2), Recombinant Protein

Popular Item
Also Known As

Recombinant A Disintegrin And Metalloproteinase With Thrombospondin 2 (ADAMTS2)

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Length
1213
Sequence
The target protein is fused with N-terminal His-Tag, its sequence is listed below.
MGHHHHHHSG S- VRHEWA LKKWSPCSKP CGGGSQFTKY GCRRRLDSKM VHRAFCSALA KPKAIRRACN PQECSQPVWV TGEWEPCTQS CGRTGMQVRS VRCIQPLHNN TTRSVHTKHC NDHRPESRRA CNRELCPGRW RAGSWSQCSV TCGNGTQERP VLCRTADDNF GVCREERPET ARICRLAPCP
Chromosome Location
Chromosome: 11; NC_000077.6 (50602085..50807573). Location: 11 B1.3; 11
3D Structure
ModBase 3D Structure for Q8C9W3
Host
E Coli
Purity/Purification
> 95%
Form/Format
Supplied as lyophilized form in PBS,pH7.4, containing 5% sucrose, 0.01% sarcosyl.
Organism
Mus musculus (Mouse)
Expression System
Prokaryotic expression
Residues
Val855~Pro1030 (Accession # Q8C9W3) with N-terminal His-Tag
Subcellular Location
Secreted, extracellular space, extracellular matrix
Endotoxin Level
<1.0EU per 1ug (determined by the LAL method)
Predicted Isoelectric Point
9.5
Reconstitution
Reconstitute in sterile PBS, pH7.2-pH7.4.
Preparation and Storage
Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months.
Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test,that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. (Referring from China Biological Products Standard,which was calculated by the Arrhenius equation.) The loss of this protein is lessthan 5% within the expiration date under appropriate storage condition.
Other Notes
Small volumes of ADAMTS2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
ADAMTS2 recombinant protein
About the Marker: Effective Size Range: 10kDa to 70kDa.
Protein bands: 10kDa, 14kDa, 18kDa, 22kDa, 26kDa, 33kDa, 44kDa and70kDa.
Double intensity bands: The 26kDa, 18kDa, 10kDa bands are at doubleintensity to make location and size approximation of proteins of interestquick and easy.
Ready-to-use: No need to heat, dilute or add reducing agents before use.
Applications Tested/Suitable for ADAMTS2 recombinant protein
SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP)

NCBI/Uniprot data below describe general gene information for ADAMTS2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Related Accession #
Molecular Weight
21.2kDa
NCBI Official Full Name
A disintegrin and metalloproteinase with thrombospondin motifs 2 isoform 1 preproprotein
NCBI Official Synonym Full Names
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 2
NCBI Official Symbol
Adamts2  [Similar Products]
NCBI Official Synonym Symbols
pNPI; PCINP; hPCPNI; ADAM-TS2; ADAMTS-2; ADAMTS-3; mKIAA4060
  [Similar Products]
NCBI Protein Information
A disintegrin and metalloproteinase with thrombospondin motifs 2; PC I-NP; ADAM-TS 2; procollagen N-proteinase; procollagen N-endopeptidase; procollagen I/II amino propeptide-processing enzyme; a disintegrin and metalloproteinase with thrombospondin repeats; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 2
UniProt Protein Name
A disintegrin and metalloproteinase with thrombospondin motifs 2
UniProt Synonym Protein Names
Procollagen I N-proteinase; PC I-NP; Procollagen I/II amino propeptide-processing enzyme; Procollagen N-endopeptidase
UniProt Gene Name
Adamts2  [Similar Products]
UniProt Synonym Gene Names
ADAM-TS 2; ADAM-TS2; ADAMTS-2; PC I-NP; pNPI  [Similar Products]
UniProt Entry Name
ATS2_MOUSE
NCBI Summary for ADAMTS2
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin repeats) family of proteinases that is involved in the proteolytic processing of procollagens. The encoded protein precursor is proteolytically processed to generate a mature, zinc-dependent enzyme. Mice lacking the encoded protein develop abnormal lungs, fragile skin and male sterility. [provided by RefSeq, Aug 2015]
UniProt Comments for ADAMTS2
ADAMTS2: Cleaves the propeptides of type I and II collagen prior to fibril assembly. Does not act on type III collagen. May also play a role in development that is independent of its role in collagen biosynthesis. Defects in ADAMTS2 are the cause of Ehlers-Danlos syndrome type 7C (EDS7C). EDS is a connective tissue disorder characterized by hyperextensible skin, atrophic cutaneous scars due to tissue fragility and joint hyperlaxity. EDS7C is marked by extremely fragile tissues, hyperextensible skin and easy bruising. Facial skin contains numerous folds, as in the cutis laxa syndrome. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.4.24.14; Secreted; Protease; Motility/polarity/chemotaxis; Secreted, signal peptide; Extracellular matrix

Cellular Component: extracellular matrix; proteinaceous extracellular matrix; extracellular region

Molecular Function: peptidase activity; hydrolase activity; zinc ion binding; metallopeptidase activity; metal ion binding; metalloendopeptidase activity

Biological Process: skin development; collagen catabolic process; collagen fibril organization; protein processing; spermatogenesis; proteolysis; lung development
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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