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ADAMTS4 recombinant protein :: A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS4) Recombinant Protein

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Catalog # MBS1070579
Unit / Price
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  0.05 mg (E-Coli)  /  $1,050 +1 FREE 8GB USB
  0.05 mg (Yeast)  /  $1,080 +1 FREE 8GB USB
  0.05 mg (Baculovirus)  /  $1,320 +1 FREE 8GB USB
  0.2 mg (E-Coli)  /  $1,415 +1 FREE 8GB USB
  0.2 mg (Yeast)  /  $1,475 +1 FREE 8GB USB
  0.05 mg (Mammalian-Cell)  /  $1,560 +1 FREE 8GB USB
  0.5 mg (E-Coli)  /  $1,565 +1 FREE 8GB USB
  0.5 mg (Yeast)  /  $1,670 +2 FREE 8GB USB
  0.1 mg (Baculovirus)  /  $1,910 +2 FREE 8GB USB
  1 mg (E-Coli)  /  $2,370 +2 FREE 8GB USB
  0.5 mg (Baculovirus)  /  $2,470 +3 FREE 8GB USB
  0.1 mg (Mammalian-Cell)  /  $2,495 +3 FREE 8GB USB
  1 mg (Yeast)  /  $2,635 +3 FREE 8GB USB
  1 mg (Baculovirus)  /  $3,795 +4 FREE 8GB USB
ADAMTS4 recombinant protein
Product Name

A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS4), Recombinant Protein

Full Product Name

Recombinant Human A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS4)

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
213-837aa, Full Length of Mature Protein
Sequence
FASLSRFVET LVVADDKMAA FHGAGLKRYL LTVMAAAAKA FKHPSIRNPV SLVVTRLVIL GSGEEGPQVG PSAAQTLRSF CAWQRGLNTP EDSDPDHFDT AILFTRQDLC GVSTCDTLGM ADVGTVCDPA RSCAIVEDDG LQSAFTAAHE LGHVFNMLHD NSKPCISLNG PLSTSRHVMA PVMAHVDPEE PWSPCSARFI TDFLDNGYGH CLLDKPEAPL HLPVTFPGKD YDADRQCQLT FGPDSRHCPQ LPPPCAALWC SGHLNGHAMC QTKHSPWADG TPCGPAQACM GGRCLHMDQL QDFNIPQAGG WGPWGPWGDC SRTCGGGVQF SSRDCTRPVP RNGGKYCEGR RTRFRSCNTE DCPTGSALTF REEQCAAYNH RTDLFKSFPG PMDWVPRYTG VAPQDQCKLT CQAQALGYYY VLEPRVVDGT PCSPDSSSVC VQGRCIHAGC DRIIGSKKKF DKCMVCGGDG SGCSKQSGSF RKFRYGYNNV VTIPAGATHI LVRQQGNPGH RSIYLALKLP DGSYALNGEY TLMPSPTDVV LPGAVSLRYS GATAASETLS GHGPLAQPLT LQVLVAGNPQ DTRLRYSFFV PRPTPSTPRP TPQDWLHRRA QILEILRRRP WAGRK
OMIM
603876
3D Structure
ModBase 3D Structure for O75173
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Human
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of ADAMTS4 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
ADAMTS4 recombinant protein
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene lacks a C-terminal TS motif. It is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The cleavage of aggrecan and brevican suggests key roles of this enzyme in arthritic disease and in the central nervous system, potentially, in the progression of glioma.
NCBI/Uniprot data below describe general gene information for ADAMTS4. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
90,065 Da
NCBI Official Full Name
A disintegrin and metalloproteinase with thrombospondin motifs 4 isoform 2
NCBI Official Synonym Full Names
ADAM metallopeptidase with thrombospondin type 1 motif 4
NCBI Official Symbol
ADAMTS4  [Similar Products]
NCBI Official Synonym Symbols
ADMP-1; ADAMTS-2; ADAMTS-4
  [Similar Products]
NCBI Protein Information
A disintegrin and metalloproteinase with thrombospondin motifs 4
UniProt Protein Name
A disintegrin and metalloproteinase with thrombospondin motifs 4
UniProt Synonym Protein Names
ADMP-1; Aggrecanase-1
UniProt Gene Name
ADAMTS4  [Similar Products]
UniProt Synonym Gene Names
KIAA0688; ADAM-TS 4; ADAM-TS4; ADAMTS-4  [Similar Products]
NCBI Summary for ADAMTS4
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of this family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene lacks a C-terminal TS motif. The encoded preproprotein is proteolytically processed to generate the mature protease. This protease is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The expression of this gene is upregulated in arthritic disease and this may contribute to disease progression through the degradation of aggrecan. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]
UniProt Comments for ADAMTS4
Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Could also be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease. Cleaves aggrecan at the '392-Glu-|-Ala-393' site.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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