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ADAMTS8 recombinant protein :: A Disintegrin And Metalloproteinase With Thrombospondin 8 (ADAMTS8) Recombinant Protein

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Catalog # MBS2011305 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Unit / Price
  0.01 mg  /  $140 +1 FREE 8GB USB
  0.05 mg  /  $260 +1 FREE 8GB USB
  0.1 mg  /  $400 +1 FREE 8GB USB
  0.2 mg  /  $495 +1 FREE 8GB USB
  0.5 mg  /  $955 +1 FREE 8GB USB
  1 mg  /  $1,415 +1 FREE 8GB USB
Product Name

A Disintegrin And Metalloproteinase With Thrombospondin 8 (ADAMTS8), Recombinant Protein

Popular Item
Full Product Name

Recombinant A Disintegrin And Metalloproteinase With Thrombospondin 8 (ADAMTS8)

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 11; NC_000011.9 (130274660..130298539, complement). Location: 11q25
OMIM
605175
3D Structure
ModBase 3D Structure for Q9UP79
Host
E Coli
Species Reactivity
Human
Purity/Purification
> 95%
Form/Format
PBS, pH7.4, containing 1mM DTT, 5% trehalose, 0.01% sarcosyl and Proclin300.
Concentration
200ug/mL (lot specific)
Source
Prokaryotic expression
Residues
Leu832~Leu889
Tags
N-terminal His-Tag
Tissue Specificity
Lung
Subcellular Location
Secreted, extracellular space, extracellular matrix
Traits
Freeze-dried powder
Predicted isoelectric point
6.3
Predicted Molecular Mass
7.6kDa
Accurate Molecular Mass
13kDa as determined by SDS-PAGE reducing conditions
Usage
Reconstitute in PBS (pH7.4) to a concentration of 0.1-1.0 mg/mL. Do not vortex
Preparation and Storage
Storage: Avoid repeated freeze/thaw cycles.Store at 2-8 degree C for one month.Aliquot and store at -80 degree C for 12 months.
Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed.The loss rate is less than 5% within the expiration date under appropriate storage condition
ISO Certification
Manufactured in an ISO 9001:2008 and ISO 13485:2003 Certified Laboratory.
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Other Notes
Small volumes of ADAMTS8 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for ADAMTS8 recombinant protein
SDS-PAGE, WB, ELISA, IP, CoIP, Purification, Amine Reactive Labeling.
(May be suitable for use in other assays to be determined by the end user.)

Sequence Information of ADAMTS8 recombinant protein
ADAMTS8 recombinant protein Sequence Information image
ADAMTS8 recombinant protein Testing Data image
NCBI/Uniprot data below describe general gene information for ADAMTS8. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
A disintegrin and metalloproteinase with thrombospondin motifs 8 preproprotein
NCBI Official Synonym Full Names
ADAM metallopeptidase with thrombospondin type 1 motif, 8
NCBI Official Symbol
ADAMTS8  [Similar Products]
NCBI Official Synonym Symbols
METH2; ADAM-TS8
  [Similar Products]
NCBI Protein Information
A disintegrin and metalloproteinase with thrombospondin motifs 8; METH-2; METH-8; ADAMTS-8; ADAM-TS 8; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 8
UniProt Protein Name
A disintegrin and metalloproteinase with thrombospondin motifs 8
UniProt Synonym Protein Names
METH-2; METH-8
UniProt Gene Name
ADAMTS8  [Similar Products]
UniProt Synonym Gene Names
METH2; ADAM-TS 8; ADAM-TS8; ADAMTS-8  [Similar Products]
UniProt Entry Name
ATS8_HUMAN
NCBI Summary for ADAMTS8
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains two C-terminal TS motifs, and disrupts angiogenesis in vivo. A number of disorders have been mapped in the vicinity of this gene, most notably lung neoplasms. [provided by RefSeq, Jul 2008]
UniProt Comments for ADAMTS8
ADAMTS8: Has anti-angiogenic properties.

Protein type: EC 3.4.24.-; Motility/polarity/chemotaxis; Secreted; Protease; Secreted, signal peptide; Cell cycle regulation

Chromosomal Location of Human Ortholog: 11q25

Cellular Component: extracellular matrix; proteinaceous extracellular matrix

Molecular Function: heparin binding; integrin binding; metallopeptidase activity; zinc ion binding; metalloendopeptidase activity; low affinity phosphate transmembrane transporter activity

Biological Process: negative regulation of cell proliferation; proteolysis
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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