NP_062629.3
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
102,580 Da
NCBI Official Full Name
double-stranded RNA-specific adenosine deaminase isoform 1
NCBI Official Synonym Full Names
adenosine deaminase, RNA-specific
NCBI Official Synonym Symbols
Adar1; mZaADAR; AV242451; Adar1p110; Adar1p150 [Similar Products]
NCBI Protein Information
double-stranded RNA-specific adenosine deaminase
UniProt Protein Name
Double-stranded RNA-specific adenosine deaminase
UniProt Synonym Protein Names
RNA adenosine deaminase 1
UniProt Synonym Gene Names
UniProt Entry Name
DSRAD_MOUSE
UniProt Comments for ADAR
ADAR: Converts multiple adenosines to inosines and creates I/U mismatched base pairs in double-helical RNA substrates without apparent sequence specificity. Has been found to modify more frequently adenosines in AU-rich regions, probably due to the relative ease of melting A/U base pairs as compared to G/C pairs. Functions to modify viral RNA genomes and may be responsible for hypermutation of certain negative-stranded viruses. Edits the messenger RNAs for glutamate receptor (GLUR) subunits by site- selective adenosine deamination. Produces low-level editing at the GLUR-B Q/R site, but edits efficiently at the R/G site and HOTSPOT1. Binds to short interfering RNAs (siRNA) without editing them and suppresses siRNA-mediated RNA interference. Binds to ILF3/NF90 and up-regulates ILF3-mediated gene expression. Isoform 1 is induced by interferon alpha. Isoform 5 is constitutively expressed. Homodimer. Isoform 1 interacts with ILF2/NF45 and ILF3/NF90. 5 isoforms of the human protein are produced by alternative promoter.
Protein type: Nucleolus; RNA-binding; EC 3.5.4.37; RNA processing; Hydrolase
Cellular Component: cytoplasm; membrane; nuclear speck; nucleolus; nucleoplasm; nucleus
Molecular Function: double-stranded RNA adenosine deaminase activity; left-handed Z-DNA binding; protein binding
Biological Process: adenosine to inosine editing; base conversion or substitution editing; defense response to virus; erythrocyte differentiation; hemopoietic progenitor cell differentiation; in utero embryonic development; miRNA-mediated gene silencing, miRNA loading onto RISC; miRNA-mediated gene silencing, production of miRNAs; negative regulation of apoptosis; negative regulation of viral genome replication; osteoblast differentiation; positive regulation of viral genome replication; pre-microRNA processing; protein export from nucleus; protein import into nucleus; response to virus; somatic diversification of immune receptors via somatic mutation
Research Articles on ADAR
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Pathways associated with ADAR elisa kit
Diseases associated with ADAR elisa kit
Organs/Tissues associated with ADAR elisa kit
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