NP_001109
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
NCBI Official Full Name
Pituitary adenylate cyclase-activating polypeptide type I receptor
NCBI Official Synonym Full Names
ADCYAP receptor type I
NCBI Protein Information
pituitary adenylate cyclase-activating polypeptide type I receptor
UniProt Protein Name
Pituitary adenylate cyclase-activating polypeptide type I receptor
UniProt Synonym Gene Names
UniProt Entry Name
PACR_HUMAN
NCBI Summary for ADCYAP1R1
This gene encodes type I adenylate cyclase activating polypeptide receptor, which is a membrane-associated protein and shares significant homology with members of the glucagon/secretin receptor family. This receptor mediates diverse biological actions of adenylate cyclase activating polypeptide 1 and is positively coupled to adenylate cyclase. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Dec 2010]
UniProt Comments for ADCYAP1R1
ADCYAP1R1: This is a receptor for PACAP-27 and PACAP-38. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. May regulate the release of adrenocorticotropin, luteinizing hormone, growth hormone, prolactin, epinephrine, and catecholamine. May play a role in spermatogenesis and sperm motility. Causes smooth muscle relaxation and secretion in the gastrointestinal tract. Belongs to the G-protein coupled receptor 2 family. 5 isoforms of the human protein are produced by alternative splicing.
Protein type: Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 2; Membrane protein, integral
Chromosomal Location of Human Ortholog: 7p14
Cellular Component: neuron projection; cell surface; tight junction; rough endoplasmic reticulum; integral to plasma membrane; plasma membrane; caveola; receptor complex; endosome
Molecular Function: ADP-ribosylation factor binding; neuropeptide binding; vasoactive intestinal polypeptide receptor activity; protein binding; receptor activity; adenylate cyclase binding
Biological Process: response to drug; G-protein coupled receptor protein signaling pathway; development of primary female sexual characteristics; cAMP-mediated signaling; response to ethanol; cell surface receptor linked signal transduction; nerve growth factor receptor signaling pathway; phospholipase C activation; adenylate cyclase activation; spermatogenesis; cell differentiation; multicellular organismal response to stress; response to estradiol stimulus; transmembrane receptor protein tyrosine kinase signaling pathway
Research Articles on ADCYAP1R1
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Products associated with ADCYAP1R1 blocking peptide
Pathways associated with ADCYAP1R1 blocking peptide
Diseases associated with ADCYAP1R1 blocking peptide
Organs/Tissues associated with ADCYAP1R1 blocking peptide
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