NP_054908.2
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
56,286 Da
NCBI Official Full Name
alpha-adducin isoform b
NCBI Official Synonym Full Names
adducin 1 (alpha)
NCBI Official Synonym Symbols
NCBI Protein Information
alpha-adducin; erythrocyte adducin alpha subunit
UniProt Protein Name
Alpha-adducin
UniProt Synonym Protein Names
Erythrocyte adducin subunit alpha
UniProt Synonym Gene Names
UniProt Entry Name
ADDA_HUMAN
NCBI Summary for ADD1
Adducins are a family of cytoskeleton proteins encoded by three genes (alpha, beta, gamma). Adducin is a heterodimeric protein that consists of related subunits, which are produced from distinct genes but share a similar structure. Alpha- and beta-adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Alpha- and gamma-adducins are ubiquitously expressed. In contrast, beta-adducin is expressed at high levels in brain and hematopoietic tissues. Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinases A and C. Alternative splicing results in multiple variants encoding distinct isoforms; however, not all variants have been fully described. [provided by RefSeq, Jul 2008]
UniProt Comments for ADD1
ADD1: a cytoskeletal protein that promotes the assembly of the spectrin-actin network. Adducin is a heterodimeric protein that consists of related subunits. Alpha- and beta-adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Alpha- and gamma-adducins are ubiquitously expressed. Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinases A and C. Three alternatively-spliced isoforms have been described.
Protein type: Motility/polarity/chemotaxis; Cytoskeletal
Chromosomal Location of Human Ortholog: 4p16.3
Cellular Component: nucleoplasm; F-actin capping protein complex; intermediate filament cytoskeleton; focal adhesion; perinuclear region of cytoplasm; postsynaptic density; dendritic spine; plasma membrane; cytosol; nucleus
Molecular Function: actin filament binding; calmodulin binding; protein homodimerization activity; spectrin binding; protein heterodimerization activity; T cell receptor binding; structural molecule activity; actin binding; transcription factor binding
Biological Process: actin filament bundle formation; positive regulation of protein binding; hemoglobin metabolic process; apoptosis; unfolded protein response; in utero embryonic development; multicellular organism growth; cell morphogenesis; positive regulation of endocytosis; positive regulation of angiogenesis; unfolded protein response, activation of signaling protein activity; cellular protein metabolic process; homeostasis of number of cells within a tissue; erythrocyte differentiation; barbed-end actin filament capping; cell volume homeostasis; actin cytoskeleton organization and biogenesis; cell structure disassembly during apoptosis
Disease: Hypertension, Essential
Research Articles on ADD1
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Products associated with ADD1 elisa kit
Pathways associated with ADD1 elisa kit
Diseases associated with ADD1 elisa kit
Organs/Tissues associated with ADD1 elisa kit
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