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AFP native protein

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Catalog # MBS537403
Unit / Price
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  0.5 mg  /  $515 +1 FREE 8GB USB
AFP native protein
Product Name

AFP, Native Protein

Popular Item
Full Product Name

AFP protein

Product Synonym Names
alpha-Fetoprotein antigen; alpha-Fetoprotein protein
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
104150
3D Structure
ModBase 3D Structure for P02771
Host
Human
Purity/Purification
> 98% by SDS-PAGE
Form/Format
Purified by ion-exchange, affinity and gel-filtration chromatography. Supplied in 0.1M PBS buffer, pH7.4 with 0.05% Na Azide.
Concentration
3.5mg/ml (lot specific)
Source Note
Human cord serum
Protein Type
Native
Biological Significance
Alpha-fetoprotein is a protein that in humans is encoded by the AFP gene. This gene encodes alpha-fetoprotein, a major plasma protein produced by the yolk sac and the liver during fetal life. The protein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein and albumin genes are present in tandem on chromosome 4. Alpha-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin.
Biohazard Information
Tested negative for HBsAg, anti-HCV and anti-HIV 1/2 by EIA.
Additional Remarks
this AFP can be used for labeling or immunization purposes
Preparation and Storage
Store at 4 degree C shipping purposes only. Upon receipt aliquot and store at -20 degree C. Avoid repeated freeze/thaw cycles.
Other Notes
Small volumes of AFP native protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
AFP native protein
Purified native Human AFP protein
Product Categories/Family for AFP native protein
Applications Tested/Suitable for AFP native protein
ELISA (EIA)
NCBI/Uniprot data below describe general gene information for AFP. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
Alpha-fetoprotein
NCBI Official Synonym Full Names
alpha-fetoprotein
NCBI Official Symbol
NCBI Official Synonym Symbols
AFPD; FETA; HPAFP
  [Similar Products]
NCBI Protein Information
alpha-fetoprotein
UniProt Protein Name
Alpha-fetoprotein
UniProt Synonym Protein Names
Alpha-1-fetoprotein; Alpha-fetoglobulin
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
HPAFP  [Similar Products]
UniProt Entry Name
FETA_HUMAN
NCBI Summary for AFP
This gene encodes alpha-fetoprotein, a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatoma or teratoma. However, hereditary persistance of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly. [provided by RefSeq, Jul 2008]
UniProt Comments for AFP
AFP: Binds copper, nickel, and fatty acids as well as, and bilirubin less well than, serum albumin. Only a small percentage (less than 2%) of the human AFP shows estrogen-binding properties. Dimeric and trimeric forms have been found in addition to the monomeric form. Plasma. Synthesized by the fetal liver and yolk sac. Belongs to the ALB/AFP/VDB family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 4q13.3

Cellular Component: extracellular space; cytoplasm

Molecular Function: metal ion binding

Biological Process: transport; progesterone metabolic process; ovulation from ovarian follicle

Disease: Alpha-fetoprotein Deficiency; Alpha-fetoprotein, Hereditary Persistence Of
Product References and Citations for AFP native protein
Simultaneous multianalysis for tumor markers by antibody fragments microarray system; Shi-Ping Songa, Bin Lia, Jun Hua, Min-Qian Li (Analytica Chimica Acta: Volume: 510 Issue: 2 Page: 147-152 DOI: 10.1016/j.aca.2004.01.020)
Regression of hepatocarcinoma cells using RNA aptamer specific to alpha-fetoprotein; Young Ju Lee, Seong-Wook Lee (Biochemical and Biophysical Research Communications: Volume: 417 Issue: 1 Page: 521-527 DOI: 10.1016/j.bbrc.2011.11.153)

Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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