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AGP7 protein :: Proteinase 3 (PR3) Protein

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Catalog # MBS844097
Unit / Price
  0.025 mg  /  $350 +1 FREE 8GB USB
Testing Data
Product Name

Proteinase 3 (PR3) (AGP7), Protein

Popular Item
Also Known As

Proteinase 3 (PR3), Human Neutrophil

Product Synonym Names
AGP7; C-ANCA antigen; Leukocyte proteinase 3; Neutrophil proteinase 4; P29; Wegener autoantigen
Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Length
256
OMIM
177020
3D Structure
ModBase 3D Structure for P24158
Host
Human Neutrophils
Purity/Purification
>=95% by SDS-PAGE
Form/Format
Frozen in 50 mM MES, pH 4.5 with 700 mM NaCl
Host Note
Human Neutrophil. Prepared from whole blood shown to be non reactive for HBsAg, anti HCV, anti HBc, and negative for anti HIV 1 & 2 by FDA approved tests.
Extinction Coefficient
1.00
Handling
Centrifuge the vial prior to opening.
Preparation and Storage
Aliquot and store at - 70°C or lower. Avoid repated freezing and thawing cycles.

Shipping: Dry Ice
Other Notes
Small volumes of AGP7 protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
AGP7 protein
Background: Proteinase 3 is one of the serine proteinases localized in azurophil granules of polymorphonuclear leukocytes. It has been identified as the autoantigen of Wegener granulomatosis, a systemic vasculitis complicated by melomonocyte proliferation. It exhibits proteolytic activity towards a range of substrates. It is physiologically inhibited by alpha1-antitrypsin. The protein has been described as having antibiotic and growth-promoting properties and causing emphysema when administered by tracheal insufflation.
Applications Tested/Suitable for AGP7 protein
SDS-PAGE

Testing Data of AGP7 protein
AGP7 protein Testing Data image
NCBI/Uniprot data below describe general gene information for AGP7. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
29 kDa
NCBI Official Full Name
myeloblastin
NCBI Official Synonym Full Names
proteinase 3
NCBI Official Symbol
PRTN3  [Similar Products]
NCBI Official Synonym Symbols
MBN; MBT; NP4; P29; PR3; ACPA; AGP7; NP-4; PR-3; CANCA; C-ANCA
  [Similar Products]
NCBI Protein Information
myeloblastin
UniProt Protein Name
Myeloblastin
UniProt Synonym Protein Names
AGP7; C-ANCA antigen; Leukocyte proteinase 3; PR-3; PR3; Neutrophil proteinase 4; NP-4; P29; Wegener autoantigen
UniProt Gene Name
PRTN3  [Similar Products]
UniProt Synonym Gene Names
MBN; PR-3; PR3; NP-4  [Similar Products]
UniProt Entry Name
PRTN3_HUMAN
UniProt Comments for AGP7
PRTN3: Polymorphonuclear leukocyte serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro) and causes emphysema when administered by tracheal insufflation to hamsters. Belongs to the peptidase S1 family. Elastase subfamily.

Protein type: EC 3.4.21.76; Protease; Cell cycle regulation

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: extracellular matrix; extracellular space; plasma membrane; cytosol

Molecular Function: enzyme binding; serine-type peptidase activity; serine-type endopeptidase activity

Biological Process: negative regulation of phagocytosis; collagen catabolic process; positive regulation of cell proliferation; blood coagulation; proteolysis
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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