NP_006399.1
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NCBI GenBank Nucleotide #
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UniProt Related Accession #
Molecular Weight
19,979 Da
NCBI Official Full Name
anterior gradient protein 2 homolog
NCBI Official Synonym Full Names
anterior gradient 2, protein disulphide isomerase family member
NCBI Official Synonym Symbols
AG2; GOB-4; HAG-2; XAG-2; PDIA17; HEL-S-116 [Similar Products]
NCBI Protein Information
anterior gradient protein 2 homolog
UniProt Protein Name
Anterior gradient protein 2 homolog
UniProt Synonym Protein Names
HPC8; Secreted cement gland protein XAG-2 homolog
UniProt Synonym Gene Names
UniProt Entry Name
AGR2_HUMAN
UniProt Comments for AGR2
AGR2: Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells. Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth. Interacts with LYPD3 and DAG1 (alphaDAG1). Interacts with MUC2; disulfide-linked. Expressed strongly in trachea, lung, stomach, colon, prostate and small intestine. Expressed weakly in pituitary gland, salivary gland, mammary gland, bladder, appendix, ovary, fetal lung, uterus, pancreas, kidney, fetal kidney, testis, placenta, thyroid gland and in estrogen receptor (ER)-positive breast cancer cell lines. Belongs to the AGR family.
Protein type: Secreted, signal peptide; Secreted; Oncoprotein
Chromosomal Location of Human Ortholog: 7p21.3
Cellular Component: endoplasmic reticulum; extracellular space; mitochondrion
Molecular Function: epidermal growth factor receptor binding; protein binding; protein homodimerization activity
Biological Process: digestive tract morphogenesis; positive regulation of developmental growth; positive regulation of epidermal growth factor receptor signaling pathway
Research Articles on AGR2
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Diseases associated with AGR2 blocking peptide
Organs/Tissues associated with AGR2 blocking peptide
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