XP_005252739.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
21,646 Da
NCBI Official Full Name
methylated-DNA--protein-cysteine methyltransferase isoform X1
NCBI Official Synonym Full Names
O-6-methylguanine-DNA methyltransferase
NCBI Protein Information
methylated-DNA--protein-cysteine methyltransferase
UniProt Protein Name
Methylated-DNA--protein-cysteine methyltransferase
UniProt Synonym Protein Names
6-O-methylguanine-DNA methyltransferase; MGMT; O-6-methylguanine-DNA-alkyltransferase
UniProt Synonym Gene Names
NCBI Summary for AGT
Alkylating agents are potent carcinogens that can result in cell death, mutation and cancer. The protein encoded by this gene is a DNA repair protein that is involved in cellular defense against mutagenesis and toxicity from alkylating agents. The protein catalyzes transfer of methyl groups from O(6)-alkylguanine and other methylated moieties of the DNA to its own molecule, which repairs the toxic lesions. Methylation of the genes promoter has been associated with several cancer types, including colorectal cancer, lung cancer, lymphoma and glioblastoma. [provided by RefSeq, Sep 2015]
UniProt Comments for AGT
MGMT: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. Belongs to the MGMT family.
Protein type: Apoptosis; DNA repair, damage; EC 2.1.1.63; Methyltransferase; Nuclear receptor co-regulator
Chromosomal Location of Human Ortholog: 10q26.3
Cellular Component: membrane; nucleoplasm; nucleus
Molecular Function: damaged DNA binding; DNA binding; DNA-methyltransferase activity; methylated-DNA-[protein]-cysteine S-methyltransferase activity; methyltransferase activity
Biological Process: DNA dealkylation; DNA ligation; negative regulation of apoptosis
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Products associated with anti-AGT antibody
Pathways associated with anti-AGT antibody
Diseases associated with anti-AGT antibody
Organs/Tissues associated with anti-AGT antibody
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