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AHCY recombinant protein :: Adenosylhomocysteinase Recombinant Protein

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Catalog # MBS958818
Unit / Price
Scan QR to view Datasheet
  0.01 mg (E-Coli)  /  $160 +1 FREE 8GB USB
  0.05 mg (E-Coli)  /  $200 +1 FREE 8GB USB
  0.1 mg (E-Coli)  /  $295 +1 FREE 8GB USB
  0.2 mg (E-Coli)  /  $480 +1 FREE 8GB USB
  0.5 mg (E-Coli)  /  $790 +1 FREE 8GB USB
  1 mg (E-Coli)  /  $1,215 +1 FREE 8GB USB
SDS-PAGE
Product Name

Adenosylhomocysteinase (AHCY), Recombinant Protein

Full Product Name

Recombinant Human Adenosylhomocysteinase

Product Synonym Names
S-adenosyl-L-homocysteine hydrolase
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
2-432aa; Full Length
Sequence
SDKLPYKVAD IGLAAWGRKA LDIAENEMPG LMRMRERYSA SKPLKGARIA GCLHMTVETA VLIETLVTLG AEVQWSSCNI FSTQDHAAAA IAKAGIPVYA WKGETDEEYL WCIEQTLYFK DGPLNMILDD GGDLTNLIHT KYPQLLPGIR GISEETTTGV HNLYKMMANG ILKVPAINVN DSVTKSKFDN LYGCRESLID GIKRATDVMI AGKVAVVAGY GDVGKGCAQA LRGFGARVII TEIDPINALQ AAMEGYEVTT MDEACQEGNI FVTTTGCIDI ILGRHFEQMK DDAIVCNIGH FDVEIDVKWL NENAVEKVNI KPQVDRYRLK NGRRIILLAE GRLVNLGCAM GHPSFVMSNS FTNQVMAQIE LWTHPDKYPV GVHFLPKKLD EAVAEAHLGK LNVKLTKLTE KQAQYLGMSC DGPFKPDHYR Y
OMIM
180960
3D Structure
ModBase 3D Structure for P23526
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
Greater than 90% as determined by SDS-PAGE. (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Preparation and Storage
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of AHCY recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
AHCY recombinant protein
Adenosylhomocysteine is a competitive inhibitor of S-adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine.
Product Categories/Family for AHCY recombinant protein

AHCY recombinant protein SDS-PAGE image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
NCBI/Uniprot data below describe general gene information for AHCY. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
63.6kD
NCBI Official Full Name
adenosylhomocysteinase isoform 1
NCBI Official Synonym Full Names
adenosylhomocysteinase
NCBI Official Symbol
NCBI Official Synonym Symbols
SAHH; adoHcyase
  [Similar Products]
NCBI Protein Information
adenosylhomocysteinase
UniProt Protein Name
Adenosylhomocysteinase
UniProt Synonym Protein Names
S-adenosyl-L-homocysteine hydrolase
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
SAHH; AdoHcyase  [Similar Products]
UniProt Entry Name
SAHH_HUMAN
NCBI Summary for AHCY
S-adenosylhomocysteine hydrolase belongs to the adenosylhomocysteinase family. It catalyzes the reversible hydrolysis of S-adenosylhomocysteine (AdoHcy) to adenosine (Ado) and L-homocysteine (Hcy). Thus, it regulates the intracellular S-adenosylhomocysteine (SAH) concentration thought to be important for transmethylation reactions. Deficiency in this protein is one of the different causes of hypermethioninemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009]
UniProt Comments for AHCY
SAHH: Adenosylhomocysteine is a competitive inhibitor of S- adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine. Defects in AHCY are the cause of hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD). A metabolic disorder characterized by hypermethioninemia associated with failure to thrive, mental and motor retardation, facial dysmorphism with abnormal hair and teeth, and myocardiopathy. Belongs to the adenosylhomocysteinase family.

Protein type: Hydrolase; EC 3.3.1.1; Other Amino Acids Metabolism - selenoamino acid; Amino Acid Metabolism - cysteine and methionine

Chromosomal Location of Human Ortholog: 20q11.22

Cellular Component: cytoplasm; cytosol; melanosome; neuron projection; nucleus

Molecular Function: adenosylhomocysteinase activity; adenyl nucleotide binding; identical protein binding; NAD binding; protein binding

Biological Process: chronic inflammatory response to antigenic stimulus; circadian sleep/wake cycle; methylation; one-carbon compound metabolic process; response to hypoxia; response to nutrient; S-adenosylhomocysteine catabolic process; S-adenosylmethionine cycle; selenium metabolic process; sulfur amino acid metabolic process; xenobiotic metabolic process

Disease: Hypermethioninemia With S-adenosylhomocysteine Hydrolase Deficiency
Product References and Citations for AHCY recombinant protein
Sequence of full length cDNA for human S-adenosylhomocysteine hydrolase.Coulter-Karis D.E., Hershfield M.S.Ann. Hum. Genet. 53:169-175(1989)

Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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