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AICDA cdna clone

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Catalog # MBS1269402
Unit / Price
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  0.01 mg Plasmid + 0.2 mL Glycerol-Stock  /  $165 +1 FREE 8GB USB
AICDA cdna clone
Product Name

AICDA, cDNA Clone

Full Product Name

AICDA cDNA Clone

Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atggacagcc tcttgatgaa ccggaggaag tttctttacc aattcaaaaa tgtccgctgg gctaagggtc ggcgtgagac ctacctgtgc tacgtagtga agaggcgtga cagtgctaca tccttttcac tggactttgg ttatcttcgc aataagaacg gctgccacgt ggaattgctc ttcctccgct acatctcgga ctgggaccta gaccctggcc gctgctaccg cgtcacctgg ttcacctcct ggagcccctg ctacgactgt gcccgacatg tggccgactt tctgcgaggg aaccccaacc tcagtctgag gatcttcacc gcgcgcctct acttctgtga ggaccgcaag gctgagcccg aggggctgcg gcggctgcac cgcgccgggg tgcaaatagc catcatgacc ttcaaagatt atttttactg ctggaatact tttgtagaaa accatgaaag aactttcaaa gcctgggaag ggctgcatga aaattcagtt cgtctctcca gacagcttcg gcgcatcctt ttgcccctgt atgaggttga tgacttacga gacgcatttc gtactttggg actttga
OMIM
605257
Vector
pENTR223.1 or pUC
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of AICDA cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for AICDA. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
22,614 Da
NCBI Official Full Name
Homo sapiens activation-induced cytidine deaminase, mRNA
NCBI Official Synonym Full Names
activation induced cytidine deaminase
NCBI Official Symbol
AICDA  [Similar Products]
NCBI Official Synonym Symbols
AID; ARP2; CDA2; HIGM2; HEL-S-284
  [Similar Products]
NCBI Protein Information
single-stranded DNA cytosine deaminase
UniProt Protein Name
Single-stranded DNA cytosine deaminase
UniProt Synonym Protein Names
Activation-induced cytidine deaminase; Cytidine aminohydrolase
UniProt Gene Name
AICDA  [Similar Products]
UniProt Synonym Gene Names
UniProt Entry Name
AICDA_HUMAN
NCBI Summary for AICDA
This gene encodes a RNA-editing deaminase that is a member of the cytidine deaminase family. The protein is involved in somatic hypermutation, gene conversion, and class-switch recombination of immunoglobulin genes. Defects in this gene are the cause of autosomal recessive hyper-IgM immunodeficiency syndrome type 2 (HIGM2). [provided by RefSeq, Feb 2009]
UniProt Comments for AICDA
AID: Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation, gene conversion, and class- switch recombination in B-lymphocytes. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation. Strongly expressed in lymph nodes and tonsils. Belongs to the cytidine and deoxycytidylate deaminase family.

Protein type: Hydrolase; EC 3.5.4.38

Chromosomal Location of Human Ortholog: 12p13

Cellular Component: cytoplasm; exosome (RNase complex); nucleus

Molecular Function: cytidine deaminase activity; protein binding; ubiquitin protein ligase binding

Biological Process: somatic diversification of immunoglobulins; somatic hypermutation of immunoglobulin genes

Disease: Immunodeficiency With Hyper-igm, Type 2
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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