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AIMP1 recombinant protein

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Catalog # MBS203997
Unit / Price
  0.01 mg  /  $310 +1 FREE 8GB USB
  0.05 mg  /  $720 +1 FREE 8GB USB
SDS-Page
Product Name

AIMP1, Recombinant Protein

Full Product Name

AIMP1, 1-336aa, Human, His tag, E Coli

Product Synonym Names
Aminoacyl tRNA synthase complex-interacting multifunctional protein 1; Aminoacyl tRNA synthase complex-interacting multifunctional protein 1; EMAP2; EMAPII; p43; SCYE1
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
MGSSHHHHHH SSGLVPRGSH MLPAVAVSEP VVLRFMIFCR LLAKMANNDA VLKRLEQKGA EADQIIEYLK QQVSLLKEKA ILQATLREEK KLRVENAKLK KEIEELKQEL IQAEIQNGVK QIPFPSGTPL HANSMVSENV IQSTAVTTVS SGTKEQIKGG TGDEKKAKEK IEKKGEKKEK KQQSIAGSAD SKPIDVSRLD LRIGCIITAR KHPDADSLYV EEVDVGEIAP RTVVSGLVNH VPLEQMQNRM VILLCNLKPA KMRGVLSQAM VMCASSPEKI EILAPPNGSV PGDRITFDAF PGEPDKELNP KKKIWEQIQP DLHTNDECVA TYKGVPFEVK GKGVCRAQTM SNSGIK
OMIM
U10117 mRNA
3D Structure
ModBase 3D Structure for Q12904
Host
E Coli
Purity/Purification
> 85% by SDS-PAGE
Form/Format
Liquid. In 20 mM Tris-HCl Buffer (pH 8.0) containing 0.2M NaCl, 2mM DTT, 10% glycerol
Concentration
0.25 mg/ml (determined by BCA assay) (lot specific)
Antigen Species
Human
Tag Information
His-tag
Preparation and Storage
Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
Other Notes
Small volumes of AIMP1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
AIMP1 recombinant protein
AIMP1, also known as EMPA2 or p43, is a cytokine that is specifically induced by apoptosis, and it is involved in the control of angiogenesis, inflammation, and wound healing. The release of this cytokine renders the tumor-associated vasculature sensitive to tumor necrosis factor. This protein is also involved in the stimulation of inflammatory responses after proteolytic cleavage in tumor cells. Recombinant human AIMP1 protein, fused to His-tag at N-terminus, was expressed in E Coli and purified by using conventional chromatography techniques.
Product Categories/Family for AIMP1 recombinant protein
Applications Tested/Suitable for AIMP1 recombinant protein
SDS-PAGE

NCBI/Uniprot data below describe general gene information for AIMP1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
39.2 kDa (356aa), confirmed by MALDI-TOF (Molecular weight on SDS-PAGE will appear higher)
NCBI Official Full Name
aminoacyl tRNA synthase complex-interacting multifunctional protein 1 isoform b
NCBI Official Synonym Full Names
aminoacyl tRNA synthetase complex interacting multifunctional protein 1
NCBI Official Symbol
AIMP1  [Similar Products]
NCBI Official Synonym Symbols
p43; HLD3; EMAP2; SCYE1; EMAPII
  [Similar Products]
NCBI Protein Information
aminoacyl tRNA synthase complex-interacting multifunctional protein 1
UniProt Protein Name
Aminoacyl tRNA synthase complex-interacting multifunctional protein 1
UniProt Synonym Protein Names
Multisynthase complex auxiliary component p43
UniProt Gene Name
AIMP1  [Similar Products]
UniProt Synonym Gene Names
EMAP2; SCYE1; EMAP-2; EMAP-II  [Similar Products]
NCBI Summary for AIMP1
The protein encoded by this gene is a cytokine that is specifically induced by apoptosis, and it is involved in the control of angiogenesis, inflammation, and wound healing. The release of this cytokine renders the tumor-associated vasculature sensitive to tumor necrosis factor. The precursor protein is identical to the p43 subunit, which is associated with the multi-tRNA synthetase complex, and it modulates aminoacylation activity of tRNA synthetase in normal cells. This protein is also involved in the stimulation of inflammatory responses after proteolytic cleavage in tumor cells. Multiple transcript variants encoding different isoforms have been found for this gene. A pseudogene has been identified on chromosome 20. [provided by RefSeq, Dec 2008]
UniProt Comments for AIMP1
Non-catalytic component of the multisynthase complex. Stimulates the catalytic activity of cytoplasmic arginyl-tRNA synthase. Binds tRNA. Possesses inflammatory cytokine activity. Negatively regulates TGF-beta signaling through stabilization of SMURF2 by binding to SMURF2 and inhibiting its SMAD7-mediated degradation. Involved in glucose homeostasis through induction of glucagon secretion at low glucose levels. Promotes dermal fibroblast proliferation and wound repair. Regulates KDELR1-mediated retention of HSP90B1/gp96 in the endoplasmic reticulum. Plays a role in angiogenesis by inducing endothelial cell migration at low concentrations and endothelian cell apoptosis at high concentrations. Induces maturation of dendritic cells and monocyte cell adhesion. Modulates endothelial cell responses by degrading HIF-1A through interaction with PSMA7.
Product References and Citations for AIMP1 recombinant protein
Zhu X., et al. (2009) Proc Natl Acad Sci u S A. 106 (37):15944-9.; Kim E., et al. (2008) J Immunol. 180 (5):2894-902.;

Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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