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AKAP10 elisa kit :: Human A kinase (PRKA) anchor protein 10 ELISA Kit

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Catalog # MBS2602826
Unit / Price
  48-Strip-Wells  /  $260 +1 FREE 8GB USB
  96-Strip-Wells  /  $405 +1 FREE 8GB USB
  5x96-Strip-Wells  /  $1,615 +2 FREE 8GB USB
  10x96-Strip-Wells  /  $2,880 +3 FREE 8GB USB
AKAP10 elisa kit
Product Name

A kinase (PRKA) anchor protein 10 (AKAP10), ELISA Kit

Also Known As

Human A-kinase anchor protein 10, mitochondrial, AKAP10 ELISA Kit

Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Request for Current Manual Insert
OMIM
604694
3D Structure
ModBase 3D Structure for O43572
Species Reactivity
Preparation and Storage
Store all reagents at 2-8 degree C.
Product Note
Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
Other Notes
Small volumes of AKAP10 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Searchable Terms forAKAP10purchase
MBS2602826 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the A kinase (PRKA) anchor protein 10 (AKAP10) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing AKAP10. The ELISA analytical biochemical technique of the MBS2602826 kit is based on AKAP10 antibody-AKAP10 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect AKAP10 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, AKAP10. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
NCBI/Uniprot data below describe general gene information for AKAP10. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
73,818 Da[Similar Products]
NCBI Official Full Name
A-kinase anchor protein 10, mitochondrial
NCBI Official Synonym Full Names
A kinase (PRKA) anchor protein 10
NCBI Official Symbol
AKAP10  [Similar Products]
NCBI Official Synonym Symbols
PRKA10; AKAP-10; D-AKAP2; D-AKAP-2
  [Similar Products]
NCBI Protein Information
A-kinase anchor protein 10, mitochondrial; protein kinase A anchoring protein 10; dual specificity A kinase-anchoring protein 2; mitochondrial A kinase PPKA anchor protein 10
UniProt Protein Name
A-kinase anchor protein 10, mitochondrial
UniProt Synonym Protein Names
Dual specificity A kinase-anchoring protein 2; D-AKAP-2; Protein kinase A-anchoring protein 10; PRKA10
Protein Family
UniProt Gene Name
AKAP10  [Similar Products]
UniProt Synonym Gene Names
AKAP-10; D-AKAP-2; PRKA10  [Similar Products]
UniProt Entry Name
AKA10_HUMAN
NCBI Summary for AKAP10
This gene encodes a member of the A-kinase anchor protein family. A-kinase anchor proteins bind to the regulatory subunits of protein kinase A (PKA) and confine the holoenzyme to discrete locations within the cell. The encoded protein is localized to mitochondria and interacts with both the type I and type II regulatory subunits of PKA. Polymorphisms in this gene may be associated with increased risk of arrhythmias and sudden cardiac death. [provided by RefSeq, May 2012]
UniProt Comments for AKAP10
AKAP10: Differentially targeted protein that binds to type I and II regulatory subunits of protein kinase A and anchors them to the mitochondria or the plasma membrane. Although the physiological relevance between PKA and AKAPS with mitochondria is not fully understood, one idea is that BAD, a proapoptotic member, is phosphorylated and inactivated by mitochondria-anchored PKA. It cannot be excluded too that it may facilitate PKA as well as G protein signal transduction, by acting as an adapter for assembling multiprotein complexes. With its RGS domain, it could lead to the interaction to G-alpha proteins, providing a link between the signaling machinery and the downstream kinase. Genetic variations in AKAP10 are a cause of susceptibility to sudden cardiac death (SCD). Unexpected rapid natural death due to cardiovascular collapse within one hour of initial symptoms. It is usually caused by the worsening of existing heart diseases. The sudden onset of symptoms, such as chest pain and cardiac arrhythmias, particularly ventricular tachycardia, can lead to the loss of consciousness and cardiac arrest followed by biological death. Increased susceptibility to sudden cardiac death may be conferred by AKAP10 variants that are associated with markers of low vagus nerve sensitivity, e.g. fast basal heart rate and low heart rate variability.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 17p11.1

Cellular Component: mitochondrion; cytoplasm; plasma membrane; cytosol

Biological Process: protein localization; blood coagulation; signal transduction

Disease: Cardiac Conduction Defect
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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