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Akap8 recombinant protein :: A-kinase anchor protein 8 (Akap8) Recombinant Protein

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Catalog # MBS1333816
Unit / Price
Scan QR to view Datasheet
  0.05 mg (E-Coli)  /  $1,115 +1 FREE 8GB USB
  0.05 mg (Yeast)  /  $1,135 +1 FREE 8GB USB
  0.05 mg (Baculovirus)  /  $1,370 +1 FREE 8GB USB
  0.2 mg (E-Coli)  /  $1,505 +1 FREE 8GB USB
  0.2 mg (Yeast)  /  $1,545 +1 FREE 8GB USB
  0.05 mg (Mammalian-Cell)  /  $1,610 +2 FREE 8GB USB
  0.5 mg (E-Coli)  /  $1,665 +2 FREE 8GB USB
  0.5 mg (Yeast)  /  $1,750 +2 FREE 8GB USB
  0.1 mg (Baculovirus)  /  $1,985 +2 FREE 8GB USB
  1 mg (E-Coli)  /  $2,505 +3 FREE 8GB USB
  0.5 mg (Baculovirus)  /  $2,545 +3 FREE 8GB USB
  0.1 mg (Mammalian-Cell)  /  $2,575 +3 FREE 8GB USB
  1 mg (Yeast)  /  $2,760 +3 FREE 8GB USB
  1 mg (Baculovirus)  /  $3,935 +4 FREE 8GB USB
Akap8 recombinant protein
Product Name

A-kinase anchor protein 8 (Akap8), Recombinant Protein

Full Product Name

Recombinant Rat A-kinase anchor protein 8 (Akap8)

Product Synonym Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
1-687aa, full length protein
Sequence
MEQSYGGYGA WSAGPANTQG TYGSGVASWQ GYENYSYYNA QNTSVPTGTP YSYGPASWEA TKASDGGLAA GSSAMHVASF APEPCTDNSD SLIAKINQRL DMLSKEGGRG GISSGGEGMQ DRDSSFRFQP YESYDSRPCM PEHTPYRPSY SYDYDFDLGT DRNGSFGGTF NDCRDPTPER GALDGFLRGR GQGRFQDRSN SSTFIRSDPF MPPSASSEPL STTWSELNYM GGRGLGGPST NRPPPSLFSQ SMAPDYSMMG MQGVGGFGGT MPYGCGRSQT RIRDWPRRRG FERFGPDNMG RKRKPFPLYE EPDAKLARAD SEGDLSENDD GAGDLRSGDE EFRGEDDLCD SRKQRGEKED EDEDVKKRRE KQRRRDRMRD RAADRIQFAC SVCKFRSFED EEIQKHLQSK FHKETLRFIS TKLPDKTVEF LQEYIINRNK KIEKRRQELL EKESPKPKPD PFKGIGQEHF FKRIEAAHCL ACDMLIPAQH QLLQRHLHSV DHNHNRRLAA EQFKKTSLHV AKSVLNNKHI VKMLEKYLKG EDPFVNETAD LETEGDENLG EEKETPEEVA AEVLAEVITA AVKAVEGDGE PAAEHSDVLA EVEGPVDTAE AGSDSHTGKL LEEQTCETAS ETRNMEDMAR GEAAEARNEA AVPAAAAGSP VPVIAIPGIL EDELEQTDAE AKDTPTE
3D Structure
ModBase 3D Structure for Q63014
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Rat
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of Akap8 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
Akap8 recombinant protein
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is located in the nucleus during interphase and is distinctly redistributed during mitosis. This protein has a cell cycle-dependent interaction with the RII subunit of PKA.
NCBI/Uniprot data below describe general gene information for Akap8. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Related Accession #
Molecular Weight
76,162 Da
NCBI Official Full Name
A-kinase anchor protein 8
NCBI Official Synonym Full Names
A-kinase anchoring protein 8
NCBI Official Symbol
Akap8  [Similar Products]
NCBI Official Synonym Symbols
Akap95
  [Similar Products]
NCBI Protein Information
A-kinase anchor protein 8
UniProt Protein Name
A-kinase anchor protein 8
UniProt Synonym Protein Names
A-kinase anchor protein 95 kDa; AKAP 95
Protein Family
UniProt Gene Name
Akap8  [Similar Products]
UniProt Synonym Gene Names
Akap95; AKAP-8; AKAP 95  [Similar Products]
NCBI Summary for Akap8
scaffolding protein that is involved in targeting type II cAMP-dependent protein kinase for cAMP-responsive nuclear events [RGD, Feb 2006]
UniProt Comments for Akap8
Anchoring protein that mediates the subcellular compartmentation of cAMP-dependent protein kinase (PKA type II) (PubMed:8125992). Acts as an anchor for a PKA-signaling complex onto mitotic chromosomes, which is required for maintenance of chromosomes in a condensed form throughout mitosis. Recruits condensin complex subunit NCAPD2 to chromosomes required for chromatin condensation; the function appears to be independent from PKA-anchoring. May help to deliver cyclin D/E to CDK4 to facilitate cell cycle progression. Required for cell cycle G2/M transition and histone deacetylation during mitosis. In mitotic cells recruits HDAC3 to the vicinity of chromatin leading to deacetylation and subsequent phosphorylation at 'Ser-10' of histone H3; in this function may act redundantly with AKAP8L. Involved in nuclear retention of RPS6KA1 upon ERK activation thus inducing cell proliferation. May be involved in regulation of DNA replication by acting as scaffold for MCM2. Enhances HMT activity of the KMT2 family MLL4/WBP7 complex and is involved in transcriptional regulation. In a teratocarcinoma cell line is involved in retinoic acid-mediated induction of developmental genes implicating H3 'Lys-4' methylation. May be involved in recruitment of active CASP3 to the nucleus in apoptotic cells. May act as a carrier protein of GJA1 for its transport to the nucleus. Seems to involved in modulation of rDNA transcription. Preferentially binds GC-rich DNA in vitro and associates to GC-rich ribosomal RNA promoters. Involved in modulation of Toll-like receptor signaling. Required for the cAMP-dependent suppression of TNF-alpha in early stages of LPS-induced macrophage activation; the function probably implicates targeting of PKA to NFKB1 ().
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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