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ALB native protein :: Albumin, Human Serum (HSA) Low B12/Low Folate Native Protein

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Catalog # MBS318400
Unit / Price
  1 kg  /  $5,620 +7 FREE 8GB USB
ALB native protein
Product Name

Albumin, Human Serum (HSA) Low B12/Low Folate, Native Protein

Popular Item
Also Known As

HSA (Low B12/Low Folate)

Product Synonym Names
Human Serum Albumin (HSA), Low B12 and Low Folate
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 4; NC_000004.11 (74269972..74287129). Location: 4q13.3
OMIM
103600
3D Structure
ModBase 3D Structure for P02768
Host
Phoresis Plasma
Specificity
Albumin, Human Serum (HSA) Low B12/Low Folate
Purity/Purification
>99.3% pure (SPE gel electrophoresis). Cohn-Oncley Cold Alcohol Procedure
Form/Format
Purified, Lyophilized
Inactivation
Not applicable
pH
6.96 (5% solution at room temperature)
Buffer
Not applicable
Preservative
No
Lyophilized
Yes
Important Note
Centrifuge before opening to ensure complete recovery of vial contents.
Warnings
All human source materials have tested negative for HIV1, HIV2, HCV and HTLV-1 antibodies; HIV1, HIV2, HBV and HCV by NAT testing; HBsAg and HIV-1 Ag; and ALT (SGPT) by FDA approved tests. No test guarantees a product to be non-infectious. There
Preparation and Storage
Short term store at 2 to 8 degree C. Long term store at -20 degree C. Avoid multiple freeze/thaw cycles.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of ALB native protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Application Notes for ALB native protein
QC Information: B-12: 33.3pg/ml (SMAC)
Folate: BDL ng/ml (SMAC)
Biobuden (5%): <100 cfu/ml by Pour Plate at 30-35 degree C after 48 hours.

Specific methodologies have not been tested using this product.
NCBI/Uniprot data below describe general gene information for ALB. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
69,367 Da[Similar Products]
NCBI Official Full Name
albumin
NCBI Official Synonym Full Names
albumin
NCBI Official Symbol
NCBI Official Synonym Symbols
PRO0883; PRO0903; PRO1341; DKFZp779N1935
  [Similar Products]
NCBI Protein Information
serum albumin; OTTHUMP00000160370; OTTHUMP00000196832; OTTHUMP00000220435; OTTHUMP00000220436; OTTHUMP00000220438; OTTHUMP00000220439; growth-inhibiting protein 20; cell growth inhibiting protein 42
UniProt Protein Name
Serum albumin
Protein Family
UniProt Gene Name
UniProt Entry Name
ALBU_HUMAN
NCBI Summary for ALB
Albumin is a soluble, monomeric protein which comprises about one-half of the blood serum protein. Albumin functions primarily as a carrier protein for steroids, fatty acids, and thyroid hormones and plays a role in stabilizing extracellular fluid volume. Albumin is a globular unglycosylated serum protein of molecular weight 65,000. Albumin is synthesized in the liver as preproalbumin which has an N-terminal peptide that is removed before the nascent protein is released from the rough endoplasmic reticulum. The product, proalbumin, is in turn cleaved in the Golgi vesicles to produce the secreted albumin. [provided by RefSeq]
UniProt Comments for ALB
Function: Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca2+, Na+, K+, fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc. Ref.33

Subcellular location: Secreted.

Tissue specificity: Plasma. Ref.35

Post-translational modification: Kenitra variant is partially O-glycosylated at Thr-620. It has two new disulfide bonds Cys-600 to Cys-602 and Cys-601 to Cys-606.Glycated in diabetic patients.Phosphorylation sites are present in the extracelllular medium.Acetylated on Lys-223 by acetylsalicylic acid.

Polymorphism: A variant structure of albumin could lead to increased binding of zinc resulting in an asymptomatic augmentation of zinc concentration in the blood. The sequence shown is that of variant albumin A.

Involvement in disease: Defects in ALB are a cause of familial dysalbuminemic hyperthyroxinemia (FDH) [

MIM:103600]. FDH is a form of euthyroid hyperthyroxinemia that is due to increased affinity of ALB for T4. It is the most common cause of inherited euthyroid hyperthyroxinemia in Caucasian population. Ref.64 Ref.65 Ref.66 Ref.67

Sequence similarities: Belongs to the ALB/AFP/VDB family.Contains 3 albumin domains.

Caution: A peptide arising from positions 166 to 174 was originally (Ref.23 and Ref.24) termed neurotensin-related peptide (NRP) or kinetensin and was thought to regulates fat digestion, lipid absorption, and blood flow.

Sequence caution: The sequence AAF22034.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence AAF69644.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence AAG35503.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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