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ALDH clia kit :: Human ALDH (Aldehyde Dehydrogenase, Mitochondrial) CLIA Kit

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Catalog # MBS2532987
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ALDH clia kit
Product Name

ALDH (Aldehyde Dehydrogenase, Mitochondrial), CLIA Kit

Full Product Name

Human ALDH (Aldehyde Dehydrogenase, Mitochondrial) CLIA Kit

Product Synonym Names
ALDH2; ALDH-E2; ALDHI; Aldehyde Dehydrogenase 2
Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Request for Current Manual Insert
Species Reactivity
Specificity
This kit recognizes natural and recombinant ALDM. No significant cross-reactivity or interference between ALDM and analogues was observed.
Assay Type
Sandwich
Detection Range
78.125-5000pg/mL
Sensitivity
Min: 46.875pg/mL; Max: 5000pg/mL
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Product Note
Our CLIA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
Other Notes
Small volumes of ALDH clia kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
ALDH clia kit
Intended Uses: This CLIA kit applies to the in vitro quantitative determination of ALDM concentrations in serum, plasma and other biological fluids.

Principle of the Assay: This kit uses Sandwich-CLIA as the method. The micro CLIA plate provided in this kit has been pre-coated with an antibody specific to ALDM. Standards or samples are added to the appropriate micro CLIA plate wells and combined with the specific antibody. Then a biotinylated detection antibody specific for ALDM and Avidin-Horseradish Peroxidase (HRP) conjugate is added to each micro plate well successively and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain ALDM, biotinylated detection antibody and Avidin-HRP conjugate will appear fluorescence. The Relative light unit (RLU) value is measured spectrophotometrically by the Chemiluminescence immunoassay analyzer. The RLU value is positively associated with the concentration of ALDM. You can calculate the concentration of ALDM in the samples by comparing the RLU value of the samples to the standard curve.
Sample Manual Insert of MBS2532987. Click to request current manual
NCBI/Uniprot data below describe general gene information for ALDH. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
56,488 Da
NCBI Official Full Name
aldehyde dehydrogenase, mitochondrial
NCBI Official Synonym Full Names
aldehyde dehydrogenase 2 family (mitochondrial)
NCBI Official Symbol
Aldh2  [Similar Products]
NCBI Protein Information
aldehyde dehydrogenase, mitochondrial
UniProt Protein Name
Aldehyde dehydrogenase, mitochondrial
UniProt Synonym Protein Names
ALDH class 2; ALDH-E2; ALDH1
UniProt Gene Name
Aldh2  [Similar Products]
UniProt Entry Name
ALDH2_RAT
UniProt Comments for ALDH
ALDH2: This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of aldehyde dehydrogenase, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of Orientals have the cytosolic isozyme but not the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among Orientals than among Caucasians could be related to the absence of a catalytically active form of the mitochondrial isozyme. The increased exposure to acetaldehyde in individuals with the catalytically inactive form may also confer greater susceptibility to many types of cancer. This gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Mar 2011]

Protein type: Carbohydrate Metabolism - butanoate; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Other Amino Acids Metabolism - beta-alanine; Carbohydrate Metabolism - propanoate; Amino Acid Metabolism - arginine and proline; Amino Acid Metabolism - histidine; Lipid Metabolism - fatty acid; Mitochondrial; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Amino Acid Metabolism - lysine degradation; Lipid Metabolism - glycerolipid; Amino Acid Metabolism - tryptophan; Secondary Metabolites Metabolism - limonene and pinene degradation; Oxidoreductase; Carbohydrate Metabolism - pyruvate; EC 1.2.1.3; Carbohydrate Metabolism - ascorbate and aldarate

Cellular Component: mitochondrion; mitochondrial matrix

Molecular Function: identical protein binding; protein binding; aldehyde dehydrogenase (NAD) activity

Biological Process: response to nicotine; response to hyperoxia; ethanol catabolic process; response to lipopolysaccharide; response to testosterone stimulus; liver development; response to progesterone stimulus; response to estradiol stimulus; cellular response to hormone stimulus; negative regulation of apoptosis
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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