NP_766120.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
55,968 Da
NCBI Official Full Name
succinate-semialdehyde dehydrogenase, mitochondrial
NCBI Official Synonym Full Names
aldhehyde dehydrogenase family 5, subfamily A1
NCBI Official Synonym Symbols
Ahd1; Ahd-1; SSADH; Ssdh1; 6330403E24Rik; D630032B01Rik; OTTMUSG00000000613 [Similar Products]
NCBI Protein Information
succinate-semialdehyde dehydrogenase, mitochondrial
UniProt Protein Name
Succinate-semialdehyde dehydrogenase, mitochondrial
UniProt Synonym Protein Names
Aldehyde dehydrogenase family 5 member A1; NAD(+)-dependent succinic semialdehyde dehydrogenase
UniProt Entry Name
SSDH_MOUSE
UniProt Comments for ALDH5A1
ALDH5A1: Catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA). Defects in ALDH5A1 are the cause of succinate semialdehyde dehydrogenase deficiency (SSADH deficiency). SSADH deficiency is a rare inborn error in the metabolism of 4-aminobutyric acid (GABA) which leads to accumulation of 4-hydroxybutyric acid in physiologic fluids of patients. The disease is characterized by severe ataxia and by mildly retarded psychomotor development. Belongs to the aldehyde dehydrogenase family.
Protein type: Carbohydrate Metabolism - butanoate; EC 1.2.1.24; Mitochondrial; Amino Acid Metabolism - alanine, aspartate and glutamate; Oxidoreductase
Cellular Component: mitochondrion
Molecular Function: aldehyde dehydrogenase (NAD) activity; carboxylic acid binding; NAD binding; oxidoreductase activity; oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; succinate-semialdehyde dehydrogenase [NAD(P)+] activity; succinate-semialdehyde dehydrogenase activity
Biological Process: acetate metabolic process; central nervous system development; galactosylceramide metabolic process; gamma-aminobutyric acid catabolic process; gamma-aminobutyric acid metabolic process; glucose metabolic process; glucosylceramide metabolic process; glutamate metabolic process; glutamine metabolic process; glutathione metabolic process; glycerophospholipid metabolic process; metabolic process; neurotransmitter catabolic process; post-embryonic development; protein homotetramerization; short-chain fatty acid metabolic process; succinate metabolic process
Research Articles on ALDH5A1
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Pathways associated with ALDH5A1 elisa kit
Diseases associated with ALDH5A1 elisa kit
Organs/Tissues associated with ALDH5A1 elisa kit
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