NP_077812.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
57,195 Da
NCBI Official Full Name
activin receptor type-1
NCBI Official Synonym Full Names
activin A receptor type 1
NCBI Protein Information
activin receptor type-1
UniProt Protein Name
Activin receptor type-1
UniProt Synonym Protein Names
Activin receptor type I; ACTR-I; Serine/threonine-protein kinase receptor R1; SKR1; TGF-B superfamily receptor type I; TSR-I
UniProt Synonym Gene Names
NCBI Summary for ALK-2 / ACVR1 / ALK2
potential transmembrane protein serine kinase that acts as an activin receptor [RGD, Feb 2006]
UniProt Comments for ALK-2 / ACVR1 / ALK2
ALK2: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin. May be involved for left-right pattern formation during embryogenesis. Interacts with FKBP1A. Interacts with FCHO1. Expressed in normal parenchymal cells, endothelial cells, fibroblasts and tumor-derived epithelial cells. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
Protein type: EC 2.7.11.30; Kinase, protein; Membrane protein, integral; Protein kinase, Ser/Thr (receptor); Protein kinase, TKL; STKR family; TKL group; Type1 subfamily
Chromosomal Location of Human Ortholog: 3q21
Cellular Component: activin receptor complex; apical part of cell; integral to plasma membrane
Molecular Function: activin binding; activin receptor activity, type I; ATP binding; growth factor binding; protein homodimerization activity; protein kinase activity; protein serine/threonine kinase activity; receptor signaling protein serine/threonine kinase activity; SMAD binding; transforming growth factor beta binding; transforming growth factor beta receptor activity, type I; transmembrane receptor protein serine/threonine kinase activity
Biological Process: activin receptor signaling pathway; acute inflammatory response; BMP signaling pathway; determination of left/right symmetry; G1/S transition of mitotic cell cycle; gastrulation; gastrulation with mouth forming second; germ cell development; heart development; in utero embryonic development; mesoderm development; mesoderm formation; negative regulation of activin receptor signaling pathway; negative regulation of signal transduction; neural crest cell migration; patterning of blood vessels; peptidyl-threonine phosphorylation; pharyngeal system development; positive regulation of bone mineralization; positive regulation of cell migration; positive regulation of osteoblast differentiation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; protein amino acid phosphorylation; regulation of ossification; regulation of skeletal muscle development; smooth muscle cell differentiation; transforming growth factor beta receptor signaling pathway; urogenital system development
Research Articles on ALK-2 / ACVR1 / ALK2
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Pathways associated with ALK-2 / ACVR1 / ALK2 recombinant protein
Diseases associated with ALK-2 / ACVR1 / ALK2 recombinant protein
Organs/Tissues associated with ALK-2 / ACVR1 / ALK2 recombinant protein
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