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Alk recombinant protein :: ALK tyrosine kinase receptor (Alk) Recombinant Protein

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Catalog # MBS953744
Unit / Price
Scan QR to view Datasheet
  0.05 mg (E-Coli)  /  $785 +1 FREE 8GB USB
  0.05 mg (Yeast)  /  $895 +1 FREE 8GB USB
  0.05 mg (Baculovirus)  /  $1,025 +1 FREE 8GB USB
  0.2 mg (E-Coli)  /  $1,050 +1 FREE 8GB USB
  0.5 mg (E-Coli)  /  $1,155 +1 FREE 8GB USB
  0.2 mg (Yeast)  /  $1,205 +1 FREE 8GB USB
  0.05 mg (Mammalian-Cell)  /  $1,275 +1 FREE 8GB USB
  0.1 mg (Baculovirus)  /  $1,305 +1 FREE 8GB USB
  0.5 mg (Yeast)  /  $1,360 +1 FREE 8GB USB
  1 mg (E-Coli)  /  $1,645 +2 FREE 8GB USB
  0.5 mg (Baculovirus)  /  $1,875 +2 FREE 8GB USB
  0.1 mg (Mammalian-Cell)  /  $1,930 +2 FREE 8GB USB
  1 mg (Yeast)  /  $2,070 +2 FREE 8GB USB
  1 mg (Baculovirus)  /  $2,490 +3 FREE 8GB USB
Alk recombinant protein
Product Name

ALK tyrosine kinase receptor (Alk), Recombinant Protein

Full Product Name

Recombinant Mouse ALK tyrosine kinase receptor (Alk) , partial

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
268-640, Fragment at the extracellular domain, include the MAM1 domain, LDL-receptor class A domain and MAM2 domain
Sequence
LECSFDFPCE LEYSPPLHNH GNQSWSWRHV PSEEASRMNL LDGPEAEHSQ EMPRGSFLLL NTSADSKHTI LSPWMRSSSD HCTLAVSVHR HLQPSGRYVA QLLPHNEAGR EILLVPTPGK HGWTVLQGRV GRPANPFRVA LEYISSGNRS LSAVDFFALK NCSEGTSPGS KMALQSSFTC WNGTVLQLGQ ACDFHQDCAQ GEDEGQLCSK LPAGFYCNFE NGFCGWTQSP LSPHMPRWQV RTLRDAHSQG HQGRALLLST TDILASEGAT VTSATFPAPM KNSPCELRMS WLIRGVLRGN VSLVLVENKT GKEQSRTVWH VATDEGLSLW QHTVLSLLDV TDRFWLQIVT WWGPGSRATV GFDNISISLD CYL
3D Structure
ModBase 3D Structure for P97793
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Mouse
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of Alk recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
Alk recombinant protein
The 2;5 chromosomal translocation is frequently associated with anaplastic large cell lymphomas (ALCLs). The translocation creates a fusion gene consisting of the ALK (anaplastic lymphoma kinase) gene and the nucleophosmin (NPM) gene: the 3 half of ALK, derived from chromosome 2, is fused to the 5 portion of NPM from chromosome 5. A recent study shows that the product of the NPM-ALK fusion gene is oncogenic. The deduced amino acid sequences reveal that ALK is a novel receptor protein-tyrosine kinase having a putative transmembrane domain and an extracellular domain. These sequences are absent in the product of the transforming NPM-ALK gene. ALK shows the greatest sequence similarity to LTK (leukocyte tyrosine kinase). ALK plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system.
NCBI/Uniprot data below describe general gene information for Alk. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
174,948 Da
NCBI Official Full Name
ALK tyrosine kinase receptor
NCBI Official Synonym Full Names
anaplastic lymphoma kinase
NCBI Official Symbol
NCBI Official Synonym Symbols
Tcrz; CD246
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NCBI Protein Information
ALK tyrosine kinase receptor
UniProt Protein Name
ALK tyrosine kinase receptor
UniProt Synonym Protein Names
Anaplastic lymphoma kinase; CD_antigen: CD246
UniProt Gene Name
UniProt Comments for Alk
Neuronal receptor tyrosine kinase that is essentially and transiently expressed in specific regions of the central and peripheral nervous systems and plays an important role in the genesis and differentiation of the nervous system. Transduces signals from ligands at the cell surface, through specific activation of the mitogen-activated protein kinase (MAPK) pathway. Phosphorylates almost exclusively at the first tyrosine of the Y-x-x-x-Y-Y motif. Following activation by ligand, ALK induces tyrosine phosphorylation of CBL, FRS2, IRS1 and SHC1, as well as of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Acts as a receptor for ligands pleiotrophin (PTN), a secreted growth factor, and midkine (MDK), a PTN-related factor, thus participating in PTN and MDK signal transduction. PTN-binding induces MAPK pathway activation, which is important for the anti-apoptotic signaling of PTN and regulation of cell proliferation. MDK-binding induces phosphorylation of the ALK target insulin receptor substrate (IRS1), activates mitogen-activated protein kinases (MAPKs) and PI3-kinase, resulting also in cell proliferation induction. Drives NF-kappa-B activation, probably through IRS1 and the activation of the AKT serine/threonine kinase. Recruitment of IRS1 to activated ALK and the activation of NF-kappa-B are essential for the autocrine growth and survival signaling of MDK.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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