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ALKBH2 cdna clone

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Catalog # MBS1271596
Unit / Price
  0.01 mg Plasmid + 0.2 mL Glycerol-Stock  /  $165 +1 FREE 8GB USB
ALKBH2 cdna clone
Product Name

ALKBH2, cDNA Clone

Also Known As

ALKBH2 cDNA Clone

Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Length
786
Sequence
atggacagat tcctggtgaa aggggctcaa gggggccttt tgaggaagca ggaggagcaa gagccaactg gagaagagcc agctgtgttg ggaggagaca aagaaagcac aaggaagagg cccaggagag aggccccagg gaatggaggc cactcagcag gccctagctg gcggcacatt cgggctgagg gcctggactg cagttacaca gtcctgtttg gcaaagctga ggcagatgag attttccaag agttggagaa agaagtagaa tattttacag gagcactggc cagagtccag gtattcggga agtggcacag tgtgcccagg aagcaggcaa cgtatggcga cgctgggctg acctacacat tttcaggcct cacgctgtct ccaaagccct ggatcccagt tctagagcgc atccgggatc acgtctctgg ggtgactgga cagaccttca actttgtgct catcaacagg tataaagatg gctgtgacca catcggggag caccgagatg atgaaagaga actggcccct gggagcccca ttgcctctgt ctccttcggt gcctgcagag actttgtctt ccggcataag gattcccgtg ggaaaagccc ctccaggagg gtggcggtgg tcaggctgcc gctggcccac gggagcttac taatgatgaa ccacccgacc aacacgcact ggtaccacag tcttcccgtg agaaagaagg ttctggctcc acgggtgaat ctgacttttc gtaaaatttt gcttactaaa aaataa
OMIM
610602
Vector
pENTR223.1 or pUC
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of ALKBH2 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for ALKBH2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
17,083 Da
NCBI Official Full Name
Homo sapiens alkB, alkylation repair homolog 2 (E. coli), mRNA
NCBI Official Synonym Full Names
alkB homolog 2, alpha-ketoglutarate dependent dioxygenase
NCBI Official Symbol
ALKBH2  [Similar Products]
NCBI Official Synonym Symbols
NCBI Protein Information
DNA oxidative demethylase ALKBH2
UniProt Protein Name
DNA oxidative demethylase ALKBH2
UniProt Synonym Protein Names
Alkylated DNA repair protein alkB homolog 2; Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2; Oxy DC1
Protein Family
UniProt Gene Name
ALKBH2  [Similar Products]
UniProt Synonym Gene Names
UniProt Entry Name
ALKB2_HUMAN
NCBI Summary for ALKBH2
The Escherichia coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the specific DNA lesions generated in single-stranded DNA. ALKBH2 and ALKBH3 (MIM 610603) are E. coli AlkB homologs that catalyze the removal of 1-methyladenine and 3-methylcytosine (Duncan et al., 2002 [PubMed 12486230]).[supplied by OMIM, Mar 2008]
UniProt Comments for ALKBH2
ALKBH2: Dioxygenase that repairs alkylated DNA and RNA containing 1-methyladenine and 3-methylcytosine by oxidative demethylation. Can also repair alkylated DNA containing 1- ethenoadenine (in vitro). Has strong preference for double- stranded DNA. Has low efficiency with single-stranded substrates. Requires molecular oxygen, alpha-ketoglutarate and iron. Belongs to the alkB family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Hydrolase; EC 1.14.11.33; Demethylase; DNA repair, damage; Oxidoreductase

Chromosomal Location of Human Ortholog: 12q24.11

Cellular Component: microtubule cytoskeleton; nucleoplasm; nucleus

Molecular Function: DNA demethylase activity; DNA-N1-methyladenine dioxygenase activity; ferrous iron binding

Biological Process: DNA dealkylation
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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