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ALPP purified protein :: ALKALINE PHOSPHATASE Purified Protein

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Catalog # MBS230076
Unit / Price
  100 Units  /  $580 +1 FREE 8GB USB
ALPP purified protein
Product Name

ALKALINE PHOSPHATASE (ALPP), Purified Protein

Full Product Name

NATIVE HUMAN ALKALINE PHOSPHATASE

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
171800
3D Structure
ModBase 3D Structure for P05187
Purity/Purification
Biuret: 95%
Form/Format
Purified
Purified AP from human placenta - liquid
Buffer Solution
Phosphate buffered saline.
Activity
1069U/mg solid1000U/mlOne unit liberates one micromole of p-nitrophenol per minute at 37 degree C, pH 10.15 in Tris buffer
Target Species
Human
Preparation and Storage
Store at -20 degree C only. Storage in frost-free freezers is not recommended. This product should be stored undiluted.
Shelf Life: 12 months from date of despatch
Other Notes
Small volumes of ALPP purified protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for ALPP purified protein
ELISA (EIA)
NCBI/Uniprot data below describe general gene information for ALPP. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
57,954 Da[Similar Products]
NCBI Official Full Name
alkaline phosphatase, placental type preproprotein
NCBI Official Synonym Full Names
alkaline phosphatase, placental
NCBI Official Symbol
NCBI Official Synonym Symbols
ALP; PALP; PLAP; PLAP-1
  [Similar Products]
NCBI Protein Information
alkaline phosphatase, placental type; alkaline phosphatase Regan isozyme; alkaline phosphomonoesterase; glycerophosphatase; placental alkaline phosphatase 1
UniProt Protein Name
Alkaline phosphatase, placental type
UniProt Synonym Protein Names
Alkaline phosphatase Regan isozyme; Placental alkaline phosphatase 1; PLAP-1
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
PLAP; PLAP-1  [Similar Products]
UniProt Entry Name
PPB1_HUMAN
NCBI Summary for ALPP
The protein encoded by this gene is an alkaline phosphatase, a metalloenzyme that catalyzes the hydrolysis of phosphoric acid monoesters. It belongs to a multigene family composed of four alkaline phosphatase isoenzymes. The enzyme functions as a homodimer and has a catalytic site containing one magnesium and two zinc ions, which are required for its enzymatic function. The protein is primarily expressed in placental and endometrial tissue; however, strong ectopic expression has been detected in ovarian adenocarcinoma, serous cystadenocarcinoma, and other ovarian cancer cells. [provided by RefSeq, Jan 2015]
UniProt Comments for ALPP
ALPP: There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2 while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme, also referred to as the heat stable form, that is expressed primarily in the placenta although it is closely related to the intestinal form of the enzyme as well as to the placental-like form. The coding sequence for this form of alkaline phosphatase is unique in that the 3' untranslated region contains multiple copies of an Alu family repeat. In addition, this gene is polymorphic and three common alleles (type 1, type 2 and type 3) for this form of alkaline phosphatase have been well characterized. [provided by RefSeq, Jul 2008]

Protein type: Membrane protein, GPI anchor; Motility/polarity/chemotaxis; Phosphatase (non-protein); Cell surface; Membrane protein, integral; Cofactor and Vitamin Metabolism - folate biosynthesis; EC 3.1.3.1

Chromosomal Location of Human Ortholog: 2q37

Cellular Component: cell surface; integral to membrane; plasma membrane

Molecular Function: alkaline phosphatase activity; zinc ion binding; magnesium ion binding

Biological Process: dephosphorylation
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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