NP_291081.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
48,696 Da
NCBI Official Full Name
protein amnionless
NCBI Official Synonym Full Names
amnionless
NCBI Protein Information
protein amnionless; type I transmembrane protein
UniProt Protein Name
Protein amnionless
UniProt Entry Name
AMNLS_MOUSE
UniProt Comments for AMN
AMN: Necessary for efficient absorption of vitamin B12. May direct the production of trunk mesoderm during development by modulating a bone morphogenetic protein (BMP) signaling pathway in the underlying visceral endoderm. Defects in AMN are a cause of recessive hereditary megaloblastic anemia 1 (RH-MGA1); also known as MGA1 Norwegian type or Imerslund-Grasbeck syndrome (I-GS). RH-MGA1 is due to selective malabsorption of vitamin B12. Defects in vitamin B12 absorption lead to impaired function of thymidine synthase. As a consequence DNA synthesis is interrupted. Rapidly dividing cells involved in erythropoiesis are particularly affected. 1 isoforms of the human protein are produced by alternative promoter.
Protein type: Membrane protein, integral
Cellular Component: extracellular space; membrane; apical part of cell; endocytic vesicle; apical plasma membrane; integral to membrane
Molecular Function: receptor binding
Biological Process: receptor-mediated endocytosis; protein localization; multicellular organismal development; Golgi to plasma membrane protein transport; cobalamin transport; excretion
Disease: Megaloblastic Anemia 1
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Pathways associated with AMN elisa kit
Diseases associated with AMN elisa kit
Organs/Tissues associated with AMN elisa kit
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