AAK28532.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
47,754 Da
NCBI Official Full Name
amnionless
NCBI Official Synonym Full Names
amnion associated transmembrane protein
NCBI Protein Information
protein amnionless
UniProt Protein Name
Protein amnionless
UniProt Entry Name
AMNLS_HUMAN
NCBI Summary for AMN
The protein encoded by this gene is a type I transmembrane protein. It is thought to modulate bone morphogenetic protein (BMP) receptor function by serving as an accessory or coreceptor, and thus facilitates or hinders BMP binding. It is known that the mouse AMN gene is expressed in the extraembryonic visceral endoderm layer during gastrulation, but it is found to be mutated in amnionless mouse. The encoded protein has sequence similarity to short gastrulation (Sog) and procollagen IIA proteins in Drosophila. [provided by RefSeq, Jul 2008]
UniProt Comments for AMN
AMN: Necessary for efficient absorption of vitamin B12. May direct the production of trunk mesoderm during development by modulating a bone morphogenetic protein (BMP) signaling pathway in the underlying visceral endoderm. Defects in AMN are a cause of recessive hereditary megaloblastic anemia 1 (RH-MGA1); also known as MGA1 Norwegian type or Imerslund-Grasbeck syndrome (I-GS). RH-MGA1 is due to selective malabsorption of vitamin B12. Defects in vitamin B12 absorption lead to impaired function of thymidine synthase. As a consequence DNA synthesis is interrupted. Rapidly dividing cells involved in erythropoiesis are particularly affected. 1 isoforms of the human protein are produced by alternative promoter.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 14q32.3
Cellular Component: apical plasma membrane; endocytic vesicle; endosome membrane; extracellular space; plasma membrane
Molecular Function: receptor binding
Biological Process: cobalamin metabolic process; cobalamin transport; Golgi to plasma membrane protein transport; lipoprotein metabolic process; receptor-mediated endocytosis
Disease: Megaloblastic Anemia 1
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Products associated with AMN elisa kit
Pathways associated with AMN elisa kit
Diseases associated with AMN elisa kit
Organs/Tissues associated with AMN elisa kit
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