AAA35524.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
9,806 Da
NCBI Official Full Name
amylin, partial
NCBI Official Synonym Full Names
islet amyloid polypeptide
NCBI Official Synonym Symbols
NCBI Protein Information
islet amyloid polypeptide; amylin; insulinoma amyloid peptide; diabetes-associated peptide; Islet amyloid polypeptide (diabetes-associated peptide; amylin)
UniProt Protein Name
Islet amyloid polypeptide
UniProt Synonym Protein Names
Amylin; Diabetes-associated peptide; DAP; Insulinoma amyloid peptide
UniProt Synonym Gene Names
UniProt Entry Name
IAPP_HUMAN
NCBI Summary for Amylin
Islet, or insulinoma, amyloid polypeptide is commonly found in pancreatic islets of patients suffering diabetes mellitus type II, or harboring an insulinoma. While the association of amylin with the development of type II diabetes has been known for some time, a direct causative role for amylin has been harder to establish. Studies suggest that amylin, like the related beta-amyloid (Abeta) associated with Alzheimer's disease, can induce apoptotic cell-death in particular cultured cells, an effect that may be relevant to the development of type II diabetes. [provided by RefSeq, Apr 2011]
UniProt Comments for Amylin
IAPP: Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism. Belongs to the calcitonin family.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 12p12.1
Cellular Component: extracellular space; cell soma; extracellular region
Molecular Function: identical protein binding; hormone activity; receptor binding
Biological Process: negative regulation of cell differentiation; cell-cell signaling; eating behavior; apoptosis; signal transduction; negative regulation of bone resorption; sensory perception of pain; endocrine pancreas development
Research Articles on Amylin
Precautions
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Products associated with Amylin elisa kit
Pathways associated with Amylin elisa kit
Diseases associated with Amylin elisa kit
Organs/Tissues associated with Amylin elisa kit
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