NP_057322.2
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
60,002 Da
NCBI Official Full Name
anaphase-promoting complex subunit 7 isoform a
NCBI Official Synonym Full Names
anaphase promoting complex subunit 7
NCBI Official Synonym Symbols
NCBI Protein Information
anaphase-promoting complex subunit 7; cyclosome subunit 7
UniProt Protein Name
Anaphase-promoting complex subunit 7
UniProt Synonym Protein Names
Cyclosome subunit 7
UniProt Synonym Gene Names
UniProt Entry Name
APC7_HUMAN
NCBI Summary for ANAPC7
This gene encodes a tetratricopeptide repeat containing component of the anaphase promoting complex/cyclosome (APC/C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for proper protein ubiquitination function of APC/C and for the interaction of APC/C with certain transcription coactivators. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008]
UniProt Comments for ANAPC7
APC7: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Belongs to the APC7 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 12q24.11
Cellular Component: nucleoplasm; anaphase-promoting complex; cytosol; nucleus
Molecular Function: protein phosphatase binding
Biological Process: positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; mitosis; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; cell division; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; mitotic cell cycle spindle assembly checkpoint; mitotic cell cycle
Research Articles on ANAPC7
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Products associated with ANAPC7 elisa kit
Pathways associated with ANAPC7 elisa kit
Diseases associated with ANAPC7 elisa kit
Organs/Tissues associated with ANAPC7 elisa kit
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