NP_001136.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
16,550 Da
NCBI Official Full Name
angiogenin
NCBI Official Synonym Full Names
angiogenin, ribonuclease, RNase A family, 5
NCBI Official Synonym Symbols
ALS9; RAA1; HEL168; RNASE4; RNASE5 [Similar Products]
NCBI Protein Information
angiogenin; RNase 5; epididymis luminal protein 168; ribonuclease 5; ribonuclease A A1
UniProt Protein Name
Angiogenin
UniProt Synonym Protein Names
Ribonuclease 5; RNase 5
UniProt Synonym Gene Names
UniProt Entry Name
ANGI_HUMAN
NCBI Summary for ANG
The protein encoded by this gene is an exceedingly potent mediator of new blood vessel formation. It hydrolyzes cellular tRNAs resulting in decreased protein synthesis and is similar to pancreatic ribonuclease. In addition, the mature peptide has antimicrobial activity against some bacteria and fungi, including S. pneumoniae and C. albicans. Alternative splicing results in two transcript variants encoding the same protein. This gene and the gene that encodes ribonuclease, RNase A family, 4 share promoters and 5' exons. Each gene splices to a unique downstream exon that contains its complete coding region. [provided by RefSeq, Aug 2014]
UniProt Comments for ANG
ANG: May function as a tRNA-specific ribonuclease that abolishes protein synthesis by specifically hydrolyzing cellular tRNAs. Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo. Defects in ANG are the cause of susceptibility to amyotrophic lateral sclerosis type 9 (ALS9). ALS is a degenerative disorder of motor neurons in the cortex, brain stem and spinal cord. ALS is characterized by muscular weakness and atrophy. Belongs to the pancreatic ribonuclease family.
Protein type: Secreted, signal peptide; RNA-binding; Cell cycle regulation; Motility/polarity/chemotaxis; EC 3.1.27.-; Nucleolus; Secreted; Extracellular matrix; Ribonuclease
Chromosomal Location of Human Ortholog: 14q11.1-q11.2
Cellular Component: angiogenin-PRI complex; extracellular space; growth cone; cell soma; nucleolus; basal lamina; nucleus
Molecular Function: heparin binding; rRNA binding; protein binding; copper ion binding; DNA binding; endonuclease activity; actin binding; peptide binding; receptor binding; ribonuclease activity
Biological Process: cell migration; negative regulation of smooth muscle cell proliferation; diacylglycerol biosynthetic process; activation of protein kinase B; response to hormone stimulus; activation of phospholipase A2; oocyte maturation; rRNA transcription; ovarian follicle development; positive regulation of protein secretion; homeostatic process; actin filament polymerization; phospholipase C activation; negative regulation of translation; response to hypoxia; cell communication; positive regulation of endothelial cell proliferation; angiogenesis; positive regulation of phosphorylation; placenta development
Disease: Amyotrophic Lateral Sclerosis 9
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Products associated with ANG elisa kit
Diseases associated with ANG elisa kit
Organs/Tissues associated with ANG elisa kit
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