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ANGPTL4 recombinant protein

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Catalog # MBS636187
Unit / Price
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  0.01 mg  /  $430 +1 FREE 8GB USB
ANGPTL4 recombinant protein
Product Name

ANGPTL4, Recombinant Protein

Popular Item
Full Product Name

ANGPTL4, Recombinant, Mouse (Angiopoietin-like Protein 4, FIAF, Fasting-induced Adipose Factor, HFARP, Hepatic Fibrinogen/Angiopoietin-related Protein)

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
aa1-410
Sequence
Mouse ANGPTL4 (aa1-410) is fused at the C-terminus to a FLAG®-tag
Chromosome Location
Chromosome: 19; NC_000019.9 (8429011..8439257). Location: 19p13.3
OMIM
605910
3D Structure
ModBase 3D Structure for Q9BY76
Purity/Purification
>90% (SDS-PAGE)
Form/Format
Supplied as a liquid from PBS, pH 7.2
Concentration
~0.5 mg/ml (lot specific)
Biological Activity
Activates ERK phosphorylation in THP-1 cells.
Source
COS-7 cells
Grade
Highly Purified
Preparation and Storage
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 6 months after receipt at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Other Notes
Small volumes of ANGPTL4 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
ANGPTL4 recombinant protein
ANGPTL4 (Angiopoietin-like protein 4) mainly expressed in endothelial cells (hypoxia-induced). Regulates angiogenesis and modulates tumorigenesis and directly regulates lipid, glucose, and energy metabolism. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage.
NCBI/Uniprot data below describe general gene information for ANGPTL4. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
NCBI Official Full Name
angiopoietin-related protein 4 isoform b
NCBI Official Synonym Full Names
angiopoietin-like 4
NCBI Official Symbol
ANGPTL4  [Similar Products]
NCBI Official Synonym Symbols
NL2; ARP4; FIAF; HARP; PGAR; HFARP; UNQ171; pp1158; ANGPTL2
  [Similar Products]
NCBI Protein Information
angiopoietin-related protein 4; fasting-induced adipose factor; PPARG angiopoietin related protein; hepatic angiopoietin-related protein; hepatic fibrinogen/angiopoietin-related protein; peroxisome proliferator-activated receptor (PPAR) gamma induced angiopoietin-related protein
UniProt Protein Name
Angiopoietin-related protein 4
UniProt Synonym Protein Names
Angiopoietin-like protein 4; Hepatic fibrinogen/angiopoietin-related protein
UniProt Gene Name
ANGPTL4  [Similar Products]
UniProt Synonym Gene Names
ARP4; HFARP; PGAR; HFARP  [Similar Products]
UniProt Entry Name
ANGL4_HUMAN
NCBI Summary for ANGPTL4
This gene encodes a glycosylated, secreted protein containing a C-terminal fibrinogen domain. The encoded protein is induced by peroxisome proliferation activators and functions as a serum hormone that regulates glucose homeostasis, lipid metabolism, and insulin sensitivity. This protein can also act as an apoptosis survival factor for vascular endothelial cells and can prevent metastasis by inhibiting vascular growth and tumor cell invasion. The C-terminal domain may be proteolytically-cleaved from the full-length secreted protein. Decreased expression of this gene has been associated with type 2 diabetes. Alternative splicing results in multiple transcript variants. This gene was previously referred to as ANGPTL2 but has been renamed ANGPTL4. [provided by RefSeq, Sep 2013]
UniProt Comments for ANGPTL4
ANGPTL4: Protein with hypoxia-induced expression in endothelial cells. May act as a regulator of angiogenesis and modulate tumorigenesis. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. May exert a protective function on endothelial cells through an endocrine action. It is directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity. In response to hypoxia, the unprocessed form of the protein accumulates in the subendothelial extracellular matrix (ECM). The matrix-associated and immobilized unprocessed form limits the formation of actin stress fibers and focal contacts in the adhering endothelial cells and inhibits their adhesion. It also decreases motility of endothelial cells and inhibits the sprouting and tube formation.

Protein type: Apoptosis; Inhibitor; Secreted; Extracellular matrix; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: extracellular space; proteinaceous extracellular matrix; extracellular region

Molecular Function: enzyme inhibitor activity; protein binding

Biological Process: positive regulation of angiogenesis; response to hypoxia; negative regulation of lipoprotein lipase activity; angiogenesis; cellular lipid metabolic process; cell differentiation; protein homooligomerization; negative regulation of apoptosis

Disease: Plasma Triglyceride Level Quantitative Trait Locus
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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