NP_006392.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
acidic leucine-rich nuclear phosphoprotein 32 family member B
NCBI Official Synonym Full Names
acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
NCBI Protein Information
acidic leucine-rich nuclear phosphoprotein 32 family member B; silver-stainable protein SSP29; acidic protein rich in leucines; putative HLA-DR-associated protein I-2
UniProt Protein Name
Acidic leucine-rich nuclear phosphoprotein 32 family member B
UniProt Synonym Protein Names
Acidic protein rich in leucines; Putative HLA-DR-associated protein I-2; PHAPI2; Silver-stainable protein SSP29
UniProt Synonym Gene Names
UniProt Entry Name
AN32B_HUMAN
UniProt Comments for ANP32B
Function: Multifunctional protein working as a cell cycle progression factor as well as a cell survival factor. Required for the progression from the G1 to the S phase. Anti-apoptotic protein which functions as a caspase-3 inhibitor. Has no phosphatase 2A (PP2A) inhibitor activity
By similarity. Exhibits histone chaperone properties, stimulating core histones to assemble into a nucleosome. Ref.15
Subunit structure: Monomer. Interacts with histones H3 and H4. Ref.15
Subcellular location: Isoform 1: Nucleus. Note: Accumulates in the nuclei at the S phase
By similarity.Isoform 2: Cytoplasm. Note: Lacks a nuclear localization signal.
Tissue specificity: Expressed in heart, lung, pancreas, prostate and in spleen, thymus and placenta. Ref.3
Domain: Histone binding is mediated by the concave surface of the LRR region.
Post-translational modification: Some glutamate residues are glycylated by TTLL8. This modification occurs exclusively on glutamate residues and results in a glycine chain on the gamma-carboxyl group
By similarity.
Sequence similarities: Belongs to the ANP32 family.Contains 4 LRR (leucine-rich) repeats.Contains 1 LRRCT domain.
Research Articles on ANP32B
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Products associated with ANP32B active protein
Diseases associated with ANP32B active protein
Organs/Tissues associated with ANP32B active protein
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