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Anxa1 recombinant protein :: Annexin A1 Recombinant Protein

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Catalog # MBS954685
Unit / Price
Scan QR to view Datasheet
  0.01 mg (Yeast)  /  $200 +1 FREE 8GB USB
  0.01 mg (E-Coli)  /  $200 +1 FREE 8GB USB
  0.05 mg (E-Coli)  /  $260 +1 FREE 8GB USB
  0.05 mg (Yeast)  /  $260 +1 FREE 8GB USB
  0.1 mg (Yeast)  /  $430 +1 FREE 8GB USB
  0.1 mg (E-Coli)  /  $430 +1 FREE 8GB USB
  0.2 mg (Yeast)  /  $680 +1 FREE 8GB USB
  0.2 mg (E-Coli)  /  $685 +1 FREE 8GB USB
  0.5 mg (Yeast)  /  $1,120 +1 FREE 8GB USB
  0.5 mg (E-Coli)  /  $1,125 +1 FREE 8GB USB
  1 mg (E-Coli)  /  $1,725 +2 FREE 8GB USB
  1 mg (Yeast)  /  $1,730 +2 FREE 8GB USB
SDS-Page
Product Name

Annexin A1 (Anxa1), Recombinant Protein

Popular Item
Full Product Name

Recombinant Mouse Annexin A1

Product Synonym Names
Annexin I; Annexin-1; Calpactin II; Calpactin-2; Chromobindin-9; Lipocortin I; Phospholipase A2 inhibitory protein; p35
Product Synonym Gene Name
Anx1; Lpc-1; Lpc1[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
MBS954685 COA
Sequence Positions
2-346aa; Full Length
Sequence
AMVSEFLKQA RFLENQEQEY VQAVKSYKGG PGSAVSPYPS FNVSSDVAAL HKAIMVKGVD EATIIDILTK RTNAQRQQIK AAYLQENGKP LDEVLRKALT GHLEEVVLAM LKTPAQFDAD ELRGAMKGLG TDEDTLIEIL TTRSNEQIRE INRVYREELK RDLAKDITSD TSGDFRKALL ALAKGDRCQD LSVNQDLADT DARALYEAGE RRKGTDVNVF TTILTSRSFP HLRRVFQNYG KYSQHDMNKA LDLELKGDIE KCLTTIVKCA TSTPAFFAEK LYEAMKGAGT RHKALIRIMV SRSEIDMNEI KVFYQKKYGI SLCQAILDET KGDYEKILVA LCGGN
3D Structure
ModBase 3D Structure for P10107
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
Greater than 90% as determined by SDS-PAGE. (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Buffer
0.2um sterile filtered 20 mM Tris-HCl, 0.5M NaCl, pH 8.0, 50% glycerol
Production Note
Special Offer: The E. coli host-expressed protein is manufactured from a stock plasmid containing the protein gene. E. coli host-expressed protein is stocked in different unit sizes ranging from as small as 10 ug to as large as 1 mg. Bulk inventory is also available. The E. coli host-expressed protein has been ordered over and over again by researchers and has stood the test of time as both a robust protein and important target for the research community. It is part of our new program to make our most popular protein targets and corresponding hosts available in expanded unit sizes and with a quick processing time. Select E. coli host-expressed protein for the fastest delivery among all hosts. Please contact us or email to support@mybiosource.com for more details.
Preparation and Storage
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of Anxa1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
Anxa1 recombinant protein
Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. This protein regulates phospholipase A2 activity. It ses to bind from two to four calcium ions with high affinity.

Anxa1 recombinant protein SDS-Page image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
NCBI/Uniprot data below describe general gene information for Anxa1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Related Accession #
Molecular Weight
42.7kD
NCBI Official Full Name
annexin A1
NCBI Official Synonym Full Names
annexin A1
NCBI Official Symbol
Anxa1  [Similar Products]
NCBI Official Synonym Symbols
Lpc1; Anx-1; Lpc-1; Anx-A1; C430014K04Rik
  [Similar Products]
NCBI Protein Information
annexin A1
UniProt Protein Name
Annexin A1
UniProt Synonym Protein Names
Annexin I; Annexin-1; Calpactin II; Calpactin-2; Chromobindin-9; Lipocortin I
Protein Family
UniProt Gene Name
Anxa1  [Similar Products]
UniProt Synonym Gene Names
Anx1; Lpc-1; Lpc1  [Similar Products]
UniProt Entry Name
ANXA1_MOUSE
UniProt Comments for Anxa1
ANXA1: a calcium/phospholipid-binding protein with which promotes membrane fusion and is involved in endocytosis. Has anti-inflammatory properties and inhibits phospholipase A2 activity. Accumulates on internalized vesicles after EGF-stimulated endocytosis, suggesting that it may be required for a late stage in inward vesiculation. Phosphorylated by PKC, EGFR and Chak1. Phosphorylation results in loss of the inhibitory activity. Annexins are a family of structurally related proteins whose common property is calcium-dependent binding to phospholipids. There are at least ten different annexins in mammalian species. Annexins do not contain signal peptides, yet some annexins (A1, A2 and A5) appear to be secreted in a physiologically regulated fashion.

Protein type: Calcium-binding; Lipid-binding

Cellular Component: apical plasma membrane; cell projection; cell surface; cilium; cornified envelope; cytoplasm; cytoplasmic vesicle; endosome; extracellular region; extracellular space; extrinsic to external side of plasma membrane; extrinsic to membrane; focal adhesion; lateral plasma membrane; mast cell granule; membrane; mitochondrial membrane; nucleoplasm; nucleus; plasma membrane; protein complex; sarcolemma; vesicle

Molecular Function: calcium ion binding; calcium-dependent phospholipid binding; calcium-dependent protein binding; double-stranded DNA-dependent ATPase activity; helicase activity; metal ion binding; phospholipase A2 inhibitor activity; phospholipase inhibitor activity; phospholipid binding; protein binding; protein binding, bridging; protein homodimerization activity; single-stranded DNA binding; single-stranded RNA binding; structural molecule activity

Biological Process: actin cytoskeleton reorganization; adaptive immune response; alpha-beta T cell differentiation; arachidonic acid secretion; cell surface receptor linked signal transduction; DNA duplex unwinding; DNA strand renaturation; G-protein signaling, coupled to cyclic nucleotide second messenger; immune system process; inflammatory response; innate immune response; insulin secretion; keratinocyte differentiation; monocyte chemotaxis; myoblast migration involved in skeletal muscle regeneration; negative regulation of exocytosis; negative regulation of protein secretion; negative regulation of T-helper 2 cell differentiation; neutrophil homeostasis; peptide cross-linking; phagocytosis; positive regulation of apoptosis; positive regulation of interleukin-2 production; positive regulation of neutrophil apoptosis; positive regulation of prostaglandin biosynthetic process; positive regulation of T cell proliferation; positive regulation of T-helper 1 cell differentiation; positive regulation of vesicle fusion; regulation of cell proliferation; regulation of cell shape; regulation of hormone secretion; regulation of inflammatory response; regulation of interleukin-1 production; regulation of leukocyte migration; signal transduction
Product References and Citations for Anxa1 recombinant protein
Mouse lipocortin I cDNA.Sakata T., Iwagami S., Tsuruta Y., Suzuki R., Hojo K., Sato K., Teraoka H.Nucleic Acids Res. 16:11818-11818(1988) Mouse lipocortin I gene structure and chromosomal assignment gene duplication and the origins of a gene family.Horlick K.R., Cheng I.C., Wong W.T., Wakeland E.K., Nick H.S.Genomics 10:365-374(1991) cDNA-cloning, sequencing and expression in glucocorticoid-stimulated quiescent Swiss 3T3 fibroblasts of mouse lipocortin I.Philipps C., Rose-John S., Rincke G., Fuerstenberger G., Marks F.Biochem. Biophys. Res. Commun. 159:155-162(1989) Dysferlin interacts with annexins A1 and A2 and mediates sarcolemmal wound-healing.Lennon N.J., Kho A., Bacskai B.J., Perlmutter S.L., Hyman B.T., Brown R.H. Jr.J. Biol. Chem. 278:50466-50473(2003) Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry.Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.Mol. Cell. Proteomics 8:904-912(2009) SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.Mol. Cell 50:919-930(2013)

Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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