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ANXA1 recombinant protein :: ANNEXIN I Recombinant Protein

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Catalog # MBS232452
Unit / Price
  0.025 mg  /  $515 +1 FREE 8GB USB
ANXA1 recombinant protein
Product Name

ANNEXIN I (ANXA1), Recombinant Protein

Also Known As

RECOMBINANT HUMAN ANNEXIN I

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Length
346
OMIM
151690
3D Structure
ModBase 3D Structure for P04083
Form/Format
Purified recombinant protein - liquid
Concentration
Total protein concentration 0.2mg/ml (lot specific)
Preparation
Purified recombinant 6xHis-tagged ANXA1 expressed in E Coli
Buffer Solution
Phosphate buffered saline
Target Species
Human
Preparation and Storage
Store at -70 degree C. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 12 months from date of despatch.
Other Notes
Small volumes of ANXA1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
ANXA1 recombinant protein
Annexin I (ANXA1), otherwise known as Lipocortin 1, is a calcium-dependent phospholipid-binding protein and member of the annexin family, preferentially expressed on the cytosolic face of the plasma membrane, which acts as an inhibitor of phospholipase A2, and may exhibit anti-inflammatory activity. Increased expression of the ANXA1 gene in hairy cell leukaemia, can be used in immunohistochemistry as a highly-sensitive diagnostic marker.
Applications Tested/Suitable for ANXA1 recombinant protein
ELISA (EIA), Western Blot (WB)
NCBI/Uniprot data below describe general gene information for ANXA1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Related Accession #
Molecular Weight
41.4kD (368 amino acid residues with tag)[Similar Products]
NCBI Official Full Name
annexin A1
NCBI Official Synonym Full Names
annexin A1
NCBI Official Symbol
ANXA1  [Similar Products]
NCBI Official Synonym Symbols
ANX1; LPC1
  [Similar Products]
NCBI Protein Information
annexin A1; annexin I (lipocortin I); annexin-1; calpactin II; calpactin-2; chromobindin-9; phospholipase A2 inhibitory protein
UniProt Protein Name
Annexin A1
UniProt Synonym Protein Names
Annexin I; Annexin-1; Calpactin II; Calpactin-2; Chromobindin-9; Lipocortin I; Phospholipase A2 inhibitory protein; p35
Protein Family
UniProt Gene Name
ANXA1  [Similar Products]
UniProt Synonym Gene Names
ANX1; LPC1  [Similar Products]
UniProt Entry Name
ANXA1_HUMAN
NCBI Summary for ANXA1
This gene encodes a membrane-localized protein that binds phospholipids. This protein inhibits phospholipase A2 and has anti-inflammatory activity. Loss of function or expression of this gene has been detected in multiple tumors. [provided by RefSeq, Dec 2014]
UniProt Comments for ANXA1
ANXA1: a calcium/phospholipid-binding protein with which promotes membrane fusion and is involved in endocytosis. Has anti-inflammatory properties and inhibits phospholipase A2 activity. Accumulates on internalized vesicles after EGF-stimulated endocytosis, suggesting that it may be required for a late stage in inward vesiculation. Phosphorylated by PKC, EGFR and Chak1. Phosphorylation results in loss of the inhibitory activity. Annexins are a family of structurally related proteins whose common property is calcium-dependent binding to phospholipids. There are at least ten different annexins in mammalian species. Annexins do not contain signal peptides, yet some annexins (A1, A2 and A5) appear to be secreted in a physiologically regulated fashion.

Protein type: Calcium-binding; Lipid-binding

Chromosomal Location of Human Ortholog: 9q21.13

Cellular Component: extracellular space; cell surface; focal adhesion; protein complex; mast cell granule; basolateral plasma membrane; extracellular region; cornified envelope; cilium; cytoplasm; mitochondrial membrane; plasma membrane; nucleus; sarcolemma; vesicle; endosome

Molecular Function: protein binding, bridging; protein binding; protein homodimerization activity; single-stranded RNA binding; calcium-dependent phospholipid binding; phospholipase A2 inhibitor activity; double-stranded DNA-dependent ATPase activity; phospholipid binding; calcium ion binding; structural molecule activity; calcium-dependent protein binding; helicase activity; single-stranded DNA binding; receptor binding

Biological Process: prostate gland development; response to drug; response to peptide hormone stimulus; positive regulation of neutrophil apoptosis; gliogenesis; alpha-beta T cell differentiation; positive regulation of vesicle fusion; signal transduction; arachidonic acid secretion; neutrophil homeostasis; endocrine pancreas development; DNA duplex unwinding; response to estradiol stimulus; regulation of cell proliferation; keratinocyte differentiation; cell surface receptor linked signal transduction; insulin secretion; DNA strand renaturation; peptide cross-linking; inflammatory response; cell motility; negative regulation of apoptosis; positive regulation of prostaglandin biosynthetic process; response to X-ray
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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