AAH50549.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
24,533 Da
NCBI Official Full Name
Amine oxidase, copper containing 3 (vascular adhesion protein 1)
NCBI Official Synonym Full Names
amine oxidase, copper containing 3
NCBI Protein Information
membrane primary amine oxidase
UniProt Protein Name
Membrane primary amine oxidase
UniProt Synonym Protein Names
Copper amine oxidase; HPAO; Semicarbazide-sensitive amine oxidase; SSAO; Vascular adhesion protein 1; VAP-1
UniProt Synonym Gene Names
UniProt Entry Name
AOC3_HUMAN
NCBI Summary for AOC3
This gene encodes a member of the semicarbazide-sensitive amine oxidase family. Copper amine oxidases catalyze the oxidative conversion of amines to aldehydes in the presence of copper and quinone cofactor. The encoded protein is localized to the cell surface, has adhesive properties as well as monoamine oxidase activity, and may be involved in leukocyte trafficking. Alterations in levels of the encoded protein may be associated with many diseases, including diabetes mellitus. A pseudogene of this gene has been described and is located approximately 9-kb downstream on the same chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013]
UniProt Comments for AOC3
AOC3: Cell adhesion protein that participates in lymphocyte recirculation by mediating the binding of lymphocytes to peripheral lymph node vascular endothelial cells in an L-selectin- independent fashion. Has a monoamine oxidase activity. May play a role in adipogenesis. Belongs to the copper/topaquinone oxidase family.
Protein type: Amino Acid Metabolism - phenylalanine; Oxidoreductase; Cell adhesion; Other Amino Acids Metabolism - beta-alanine; Amino Acid Metabolism - glycine, serine and threonine; EC 1.4.3.21; Amino Acid Metabolism - tyrosine; Membrane protein, integral
Chromosomal Location of Human Ortholog: 17q21
Cellular Component: cell surface; microvillus; cytoplasm; plasma membrane; integral to membrane
Molecular Function: amine oxidase activity; protein binding; copper ion binding; protein homodimerization activity; protein heterodimerization activity; cation channel activity; calcium ion binding; quinone binding
Biological Process: response to antibiotic; amine metabolic process; inflammatory response; cell adhesion; cation transport
Research Articles on AOC3
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Pathways associated with AOC3 elisa kit
Diseases associated with AOC3 elisa kit
Organs/Tissues associated with AOC3 elisa kit
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